Interactive Dendritic Spine Analysis Based on 3D Morphological Features

Jun Young Choi, Sang Eun Lee, Eunji Cho, Yutaro Kashiwagi, Shigeo Okabe, Sunghoe Chang, Won Ki Jeong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Dendritic spines are submicron scale protrusions on neuronal dendrites that form the postsynaptic sites of excitatory neuronal inputs. The morphological changes of dendritic spines reflect alterations in physiological conditions and are further indicators of various neuropsychiatric conditions. However, due to the highly dynamic and heterogeneous nature of spines, accurate measurement and object analysis of spine morphology is a major challenge in neuroscience research. Here, we propose an interactive 3D dendritic spine analysis system that displays 3D rendering of spines and plots the high-dimensional features extracted from the 3D mesh of spines in three graph types (parallel coordinate plot, radar plot, and 2D scatter plot with t-Distributed Stochastic Neighbor Embedding). With this system, analysts can effectively explore and analyze the dendritic spine in a 3D manner with high-dimensional features. For the system, we have constructed a set of morphological high-dimensional features from the 3D mesh of dendritic spines.

Original languageEnglish
Title of host publication2019 IEEE Visualization Conference, VIS 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages171-175
Number of pages5
ISBN (Electronic)9781728149417
DOIs
StatePublished - Oct 2019
Event2019 IEEE Visualization Conference, VIS 2019 - Vancouver, Canada
Duration: 20 Oct 201925 Oct 2019

Publication series

Name2019 IEEE Visualization Conference, VIS 2019

Conference

Conference2019 IEEE Visualization Conference, VIS 2019
CountryCanada
CityVancouver
Period20/10/1925/10/19

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Keywords

  • Biomedical and Medical Visualization
  • Coordinated and Multiple Views
  • User Interfaces

Cite this

Choi, J. Y., Lee, S. E., Cho, E., Kashiwagi, Y., Okabe, S., Chang, S., & Jeong, W. K. (2019). Interactive Dendritic Spine Analysis Based on 3D Morphological Features. In 2019 IEEE Visualization Conference, VIS 2019 (pp. 171-175). [8933795] (2019 IEEE Visualization Conference, VIS 2019). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/VISUAL.2019.8933795