Innate lymphoid cells and asthma

Sanhong Yu, Hye Young Kim, Ya Jen Chang, Rosemarie H. Dekruyff, Dale T. Umetsu

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype characterized by TH2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes, such as asthma associated with exposure to air pollution, infection, or obesity, that require innate rather than adaptive immunity. These innate pathways that lead to asthma involve macrophages, neutrophils, natural killer T cells, and innate lymphoid cells, newly described cell types that produce a variety of cytokines, including IL-5 and IL-13. We review the recent data regarding innate lymphoid cells and their role in asthma.

Original languageEnglish
Pages (from-to)943-950
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume133
Issue number4
DOIs
StatePublished - Apr 2014

Fingerprint

Asthma
Lymphocytes
Adaptive Immunity
Phenotype
Cytokines
Natural Killer T-Cells
Interleukin-13
Interleukin-5
Air Pollution
Allergens
Neutrophils
Obesity
Macrophages
Infection

Keywords

  • Airway hyperreactivity
  • allergy
  • asthma
  • influenza
  • innate lymphoid cells
  • natural killer T cells

Cite this

Yu, Sanhong ; Kim, Hye Young ; Chang, Ya Jen ; Dekruyff, Rosemarie H. ; Umetsu, Dale T. / Innate lymphoid cells and asthma. In: Journal of Allergy and Clinical Immunology. 2014 ; Vol. 133, No. 4. pp. 943-950.
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Yu, S, Kim, HY, Chang, YJ, Dekruyff, RH & Umetsu, DT 2014, 'Innate lymphoid cells and asthma', Journal of Allergy and Clinical Immunology, vol. 133, no. 4, pp. 943-950. https://doi.org/10.1016/j.jaci.2014.02.015

Innate lymphoid cells and asthma. / Yu, Sanhong; Kim, Hye Young; Chang, Ya Jen; Dekruyff, Rosemarie H.; Umetsu, Dale T.

In: Journal of Allergy and Clinical Immunology, Vol. 133, No. 4, 04.2014, p. 943-950.

Research output: Contribution to journalReview article

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AU - Umetsu, Dale T.

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