Abstract
Derived from a common precursor cell, the balance between Th17 and Treg cells must be maintained within immune system to prevent autoimmune diseases. IL-1β-mediated IL-1 receptor (IL-1R) signaling is essential for Th17-cell biology. Fine-tuning of IL-1R signaling is controlled by two receptors, IL-1RI and IL-RII, IL-1R accessory protein, and IL-1R antagonist. We demonstrate that the decoy receptor, IL-1RII, is important for regulating IL-17 responses in TCR-stimulated CD4+ T cells expressing functional IL-1RI via limiting IL-1β responsiveness. IL-1RII expression is regulated by NFAT via its interaction with Foxp3. The NFAT/FOXP3 complex binds to the IL-1RII promoter and is critical for its transcription. Additionally, IL-1RII expression is dysregulated in CD4+ T cells from patients with rheumatoid arthritis. Thus, differential expression of IL-1Rs on activated CD4+ T cells defines unique immunological features and a novel molecular mechanism underlies IL-1RII expression. These findings shed light on the modulatory effects of IL-1RII on Th17 responses.
Original language | English |
---|---|
Article number | e61841 |
Pages (from-to) | 1-72 |
Number of pages | 72 |
Journal | eLife |
Volume | 10 |
DOIs | |
State | Published - Jan 2021 |
Bibliographical note
Publisher Copyright:© 2021, eLife Sciences Publications Ltd. All rights reserved.
Keywords
- Foxp3
- IL-1 receptor
- IL-1β
- NFAT
- Rheumatoid arthritis (RA)
- Th17