Increasing prevalence of antimicrobial resistance in urinary tract infections of neurological patients, Seoul, South Korea, 2007–2016

Hye Rim Shin, Jangsup Moon, Han Sang Lee, Seon Jae Ahn, Tae Joon Kim, Jin Sun Jun, Jun Sang Sunwoo, Soon Tae Lee, Keun Hwa Jung, Kyung Il Park, Ki Young Jung, Manho Kim, Sang Kun Lee, Kon Chu

Research output: Contribution to journalArticle

Abstract

Objectives: Urinary tract infection (UTI) is a common medical complication experienced by patients with neurologic diseases. In this study, we established the microbial etiologies of UTI, and resistances to antibiotics in UTI as well as determining which appropriate empirical antibiotics should be used to treat UTI in neurological patients. Designs and methods: We retrospectively reviewed microbial etiologies and antimicrobial resistance among patients experiencing UTI events in the neurology ward of Seoul National University Hospital from 2007 to 2016. Results: The total number of UTI events observed was 301, and Klebsiella pneumoniae was the most common pathogen observed in UTIs. But in catheter-associated UTI (CAUTI), Enterococcus species were the most prevalent pathogens. Susceptibility to commonly-prescribed antibiotics decreased over 10 years, indicating increased antibiotic resistance in pathogens associated with UTI. ESBL-producing K. pneumoniae increased significantly, while increases of MDR K. pneumoniae, ESBL-producing E. coli, and VRE were not observed. Conclusions: The worldwide trend of increasing drug-resistant pathogens should be considered, and further studies on antibiotics resistance in UTI are needed. These data will greatly assist physicians when they select antibiotics to treat UTIs in neurological patients.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalInternational Journal of Infectious Diseases
Volume84
DOIs
StatePublished - Jul 2019

Keywords

  • Anti-bacterial agents
  • Bacterial
  • Drug resistance
  • Microbiological phenomena
  • Urinary tract infections

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