Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance

Sung Hee Choi, Henry N. Ginsberg

Research output: Contribution to journalReview article

153 Citations (Scopus)

Abstract

Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of VLDL and increased plasma triglycerides, as well as with hepatic steatosis, despite the increased VLDL secretion. Here we link IR with increased VLDL secretion and hepatic steatosis at both the physiologic and molecular levels. Increased VLDL secretion, together with the downstream effects on high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) size, is proatherogenic. Hepatic steatosis is a risk factor for steatohepatitis and cirrhosis. Understanding the complex inter-relationships between IR and these abnormalities of liver lipid homeostasis will provide insights relevant to new therapies for these increasing clinical problems.

Original languageEnglish
Pages (from-to)353-363
Number of pages11
JournalTrends in Endocrinology and Metabolism
Volume22
Issue number9
DOIs
StatePublished - 1 Sep 2011

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VLDL Lipoproteins
Insulin Resistance
Liver
Carbohydrate Metabolism
Fatty Liver
LDL Lipoproteins
Lipid Metabolism
HDL Cholesterol
Lipoproteins
Triglycerides
Homeostasis
Fibrosis
Lipids
Therapeutics

Cite this

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abstract = "Insulin resistance (IR) affects not only the regulation of carbohydrate metabolism but all aspects of lipid and lipoprotein metabolism. IR is associated with increased secretion of VLDL and increased plasma triglycerides, as well as with hepatic steatosis, despite the increased VLDL secretion. Here we link IR with increased VLDL secretion and hepatic steatosis at both the physiologic and molecular levels. Increased VLDL secretion, together with the downstream effects on high density lipoprotein (HDL) cholesterol and low density lipoprotein (LDL) size, is proatherogenic. Hepatic steatosis is a risk factor for steatohepatitis and cirrhosis. Understanding the complex inter-relationships between IR and these abnormalities of liver lipid homeostasis will provide insights relevant to new therapies for these increasing clinical problems.",
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Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. / Choi, Sung Hee; Ginsberg, Henry N.

In: Trends in Endocrinology and Metabolism, Vol. 22, No. 9, 01.09.2011, p. 353-363.

Research output: Contribution to journalReview article

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