Increased risk of atrial fibrillation in patients with Behçet's disease

A nationwide population-based study

Euijae Lee, Eue-Keun Choi, Jin Hyung Jung, Kyung Do Han, So Ryoung Lee, Myung Jin Cha, Woo Hyun Lim, Seil Oh

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Chronic inflammation plays a role in the pathophysiology of atrial fibrillation (AF). However, there is a paucity of information about whether Behçet's disease (BD) is associated with an increased risk of AF. This population-based study aimed to determine the risk of AF in patients with BD. Methods: A total of 6636 newly diagnosed BD patients without a history of AF were included from the Korean National Health Insurance Service database between 2010 and 2014. Newly diagnosed non-valvular AF was identified using the claims data. An age- and sex-matched non-BD subjects were extracted at a ratio of 1:5 (n = 31,040). The incidence and risk of AF were compared between groups. Results: During a mean follow-up of 3.6 ± 1.5 years, AF was newly diagnosed in 173 patients (51 in the BD group, 122 in the control group). The incidence was 2.3 and 1.1 per 1000 person-years, respectively. After adjustment, the BD group showed a 1.8-fold higher risk of AF compared to the control group. Patients with BD aged ≤40 years had a higher risk of AF, while patients aged ≥65 years showed a similar risk. Men with BD had a 2.5-fold increased risk of AF, whereas women with BD did not. Severe BD had a higher risk for AF compared to non-severe BD and controls. Conclusions: BD was associated with an increased risk of AF, particularly in men and young patients. Active surveillance and treatment are needed in BD patients and those with arrhythmic symptoms.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalInternational Journal of Cardiology
Volume292
DOIs
StatePublished - 1 Oct 2019

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Atrial Fibrillation
Population
National Health Programs
Control Groups
Incidence
Databases
Inflammation

Keywords

  • Atrial fibrillation, incidence
  • Behçet's disease
  • Epidemiology

Cite this

Lee, Euijae ; Choi, Eue-Keun ; Jung, Jin Hyung ; Han, Kyung Do ; Lee, So Ryoung ; Cha, Myung Jin ; Lim, Woo Hyun ; Oh, Seil. / Increased risk of atrial fibrillation in patients with Behçet's disease : A nationwide population-based study. In: International Journal of Cardiology. 2019 ; Vol. 292. pp. 106-111.
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title = "Increased risk of atrial fibrillation in patients with Beh{\cc}et's disease: A nationwide population-based study",
abstract = "Background: Chronic inflammation plays a role in the pathophysiology of atrial fibrillation (AF). However, there is a paucity of information about whether Beh{\cc}et's disease (BD) is associated with an increased risk of AF. This population-based study aimed to determine the risk of AF in patients with BD. Methods: A total of 6636 newly diagnosed BD patients without a history of AF were included from the Korean National Health Insurance Service database between 2010 and 2014. Newly diagnosed non-valvular AF was identified using the claims data. An age- and sex-matched non-BD subjects were extracted at a ratio of 1:5 (n = 31,040). The incidence and risk of AF were compared between groups. Results: During a mean follow-up of 3.6 ± 1.5 years, AF was newly diagnosed in 173 patients (51 in the BD group, 122 in the control group). The incidence was 2.3 and 1.1 per 1000 person-years, respectively. After adjustment, the BD group showed a 1.8-fold higher risk of AF compared to the control group. Patients with BD aged ≤40 years had a higher risk of AF, while patients aged ≥65 years showed a similar risk. Men with BD had a 2.5-fold increased risk of AF, whereas women with BD did not. Severe BD had a higher risk for AF compared to non-severe BD and controls. Conclusions: BD was associated with an increased risk of AF, particularly in men and young patients. Active surveillance and treatment are needed in BD patients and those with arrhythmic symptoms.",
keywords = "Atrial fibrillation, incidence, Beh{\cc}et's disease, Epidemiology",
author = "Euijae Lee and Eue-Keun Choi and Jung, {Jin Hyung} and Han, {Kyung Do} and Lee, {So Ryoung} and Cha, {Myung Jin} and Lim, {Woo Hyun} and Seil Oh",
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Increased risk of atrial fibrillation in patients with Behçet's disease : A nationwide population-based study. / Lee, Euijae; Choi, Eue-Keun; Jung, Jin Hyung; Han, Kyung Do; Lee, So Ryoung; Cha, Myung Jin; Lim, Woo Hyun; Oh, Seil.

In: International Journal of Cardiology, Vol. 292, 01.10.2019, p. 106-111.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Increased risk of atrial fibrillation in patients with Behçet's disease

T2 - A nationwide population-based study

AU - Lee, Euijae

AU - Choi, Eue-Keun

AU - Jung, Jin Hyung

AU - Han, Kyung Do

AU - Lee, So Ryoung

AU - Cha, Myung Jin

AU - Lim, Woo Hyun

AU - Oh, Seil

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Chronic inflammation plays a role in the pathophysiology of atrial fibrillation (AF). However, there is a paucity of information about whether Behçet's disease (BD) is associated with an increased risk of AF. This population-based study aimed to determine the risk of AF in patients with BD. Methods: A total of 6636 newly diagnosed BD patients without a history of AF were included from the Korean National Health Insurance Service database between 2010 and 2014. Newly diagnosed non-valvular AF was identified using the claims data. An age- and sex-matched non-BD subjects were extracted at a ratio of 1:5 (n = 31,040). The incidence and risk of AF were compared between groups. Results: During a mean follow-up of 3.6 ± 1.5 years, AF was newly diagnosed in 173 patients (51 in the BD group, 122 in the control group). The incidence was 2.3 and 1.1 per 1000 person-years, respectively. After adjustment, the BD group showed a 1.8-fold higher risk of AF compared to the control group. Patients with BD aged ≤40 years had a higher risk of AF, while patients aged ≥65 years showed a similar risk. Men with BD had a 2.5-fold increased risk of AF, whereas women with BD did not. Severe BD had a higher risk for AF compared to non-severe BD and controls. Conclusions: BD was associated with an increased risk of AF, particularly in men and young patients. Active surveillance and treatment are needed in BD patients and those with arrhythmic symptoms.

AB - Background: Chronic inflammation plays a role in the pathophysiology of atrial fibrillation (AF). However, there is a paucity of information about whether Behçet's disease (BD) is associated with an increased risk of AF. This population-based study aimed to determine the risk of AF in patients with BD. Methods: A total of 6636 newly diagnosed BD patients without a history of AF were included from the Korean National Health Insurance Service database between 2010 and 2014. Newly diagnosed non-valvular AF was identified using the claims data. An age- and sex-matched non-BD subjects were extracted at a ratio of 1:5 (n = 31,040). The incidence and risk of AF were compared between groups. Results: During a mean follow-up of 3.6 ± 1.5 years, AF was newly diagnosed in 173 patients (51 in the BD group, 122 in the control group). The incidence was 2.3 and 1.1 per 1000 person-years, respectively. After adjustment, the BD group showed a 1.8-fold higher risk of AF compared to the control group. Patients with BD aged ≤40 years had a higher risk of AF, while patients aged ≥65 years showed a similar risk. Men with BD had a 2.5-fold increased risk of AF, whereas women with BD did not. Severe BD had a higher risk for AF compared to non-severe BD and controls. Conclusions: BD was associated with an increased risk of AF, particularly in men and young patients. Active surveillance and treatment are needed in BD patients and those with arrhythmic symptoms.

KW - Atrial fibrillation, incidence

KW - Behçet's disease

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