Increased pulsatility index of the basilar artery is a risk factor for neurological deterioration after stroke: a case control study

Il Han Yoo, Jeong Min Kim, Su Hyun Han, Jaiyoung Ryu, Keun Hwa Jung, Kwang Yeol Park

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Higher pulsatility of the middle cerebral artery (MCA) is known to be associated with stroke progression. We investigated whether pulsatility index (PI) of the basilar artery (BA) can predict neurological deterioration (ND) after acute cerebral infarction. Methods: A total of 708 consecutive patients with acute ischemic stroke who had undergone transcranial Doppler (TCD) ultrasonography were included. ND was defined as an increase in the National Institutes of Health Stroke Scale scores by two or more points after admission. The patients were categorized into quartiles according to BA PI. Multivariable logistic regression analysis was performed to examine whether BA PI is independently associated with ND. Results: BA PI was well correlated with the right (n = 474, r2 = 0.573, P < 0.001) by Pearson correlation analysis although MCA PI could not be measured from right MCA (n = 234, 33.05%) and left MCA (n = 252, 35.59%) by TCD owing to insufficient temporal bone window. Multivariable logistic regression analysis including age, sex, cerebral atherosclerosis burden, National Institutes of Health Stroke Scale at admission, and the proportion of patients with current smoking status, hypertension, diabetes mellitus, atrial fibrillation revealed that the higher BA PI (odds ratio, 3.28; confidence interval, 1.07–10.17; P = 0.038) was independently associated with ND. Conclusions: BA PI, which would be identified regardless of temporal window, could predict ND among acute stroke patients.

Original languageEnglish
Article number27
JournalClinical Hypertension
Volume28
Issue number1
DOIs
StatePublished - Dec 2022
Externally publishedYes

Keywords

  • Basilar artery
  • Neurological deterioration
  • Stroke
  • Transcranial Doppler sonography

Fingerprint

Dive into the research topics of 'Increased pulsatility index of the basilar artery is a risk factor for neurological deterioration after stroke: a case control study'. Together they form a unique fingerprint.

Cite this