Incidence of ionized hypomagnesemia in adult patients undergoing non-cardiac major surgery: a prospective observational trial

Hyun Jung Shin, Jiwon Han, Subin Yim, Sang Hwan Do

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The present study aimed to investigate the incidence of preoperative ionized hypomagnesemia and compare with that of total hypomagnesemia. Methods: This prospective observational study included 536 patients aged >20 years who were scheduled for elective surgery. Total and ionized magnesium levels were evaluated before and after the surgery. Based on these levels, patients were classified into the following groups: ionized hypo-(<0.42 mmol/L), normo-(0.42-0.59 mmol/L) and hypermagnesemia (>0.59 mmol/ L), as well as total hypo-(<1.9 mg/dL [0.78 mmol/L]), normo-(1.9-2.7 mg/dL [0.78-1.11 mmol/L]) and hypermagnesemia (>2.7 mg/dL [1.11 mmol/L]). The primary objective was to establish the incidence of preoperative ionized hypomagnesemia. Results: There was a marked difference between the incidence of preoperative ionized and total hypomagnesemia (28% vs. 19%; p<0.001). The postoperative values of ionized magnesium, ionized calcium, and albumin were significantly lower than the respective preoperative values (p<0.001 for all three variables). Conclusion: The incidence of hypomagnesemia, determined by ionized magnesium concentration, was higher than that determined by total magnesium concentration.

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalMagnesium Research
Volume35
Issue number1
DOIs
StatePublished - 1 Jan 2022

Keywords

  • hypomagnesemia
  • ionized magnesium
  • total magnesium

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