Incidence and predictors of venous thromboembolism in medically ill hospitalized elderly cancer patients

a prospective observational study

Jeong Ok Lee, Ji Yun Lee, Eun Ju Chun, Sangil Choi, Jin Won Kim, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Jong Seok Lee, Soo Mee Bang

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: The aim of this study was to estimate the incidence and predictors of venous thromboembolism (VTE) in medically ill hospitalized elderly cancer patients in a single Korean tertiary hospital. Methods: Patients were examined for deep vein thrombosis (DVT) by duplex and color Doppler ultrasonography (DUS) of both legs between days 5 and 14 of their hospital stays. The primary endpoint was the incidence of VTE by day 14, which was determined via a composite of DVT detected by routine DUS and symptomatic VTE. Results: A total of 140 patients with 31 hematologic and 109 nonhematologic malignancies were analyzed. The median age was 73 years, and 45.7% of the patients were female. The median length of hospital stay was 12 days. The modified Padua prediction score (PPS) ≥ 4 was 92.9%. The incidence of VTE by day 14 was 7.1%, including six proximal and four distal DVT cases. Being female, having a length of hospital stay of ≥ 13 days, and having a modified Padua prediction score of ≥ 6 were risk factors of VTE in univariate analysis. The incidence of VTE was 2.3%, 7.3%, and 41.7% in patients with 0–1, 2, and 3 of these risk factors, respectively. Conclusion: The incidence of VTE in medically ill hospitalized elderly cancer patients was lower in Korean patients than in Western patients. However, the risk of VTE in those with more than two risk factors (female, long length of hospitalization, and high PPS) increased considerably, and pharmacologic thromboprophylaxis is warranted in these cases.

Original languageEnglish
Pages (from-to)2507-2515
Number of pages9
JournalSupportive Care in Cancer
Volume27
Issue number7
DOIs
StatePublished - 1 Jul 2019

Fingerprint

Venous Thromboembolism
Observational Studies
Prospective Studies
Incidence
Length of Stay
Neoplasms
Venous Thrombosis
Doppler Duplex Ultrasonography
Doppler Color Ultrasonography
Doppler Ultrasonography
Tertiary Care Centers
Leg
Hospitalization

Keywords

  • Cancer
  • Elderly
  • Hospitalized
  • Risk factors
  • Venous thromboembolism

Cite this

@article{72cee7f66eb74794a67b171500ec2654,
title = "Incidence and predictors of venous thromboembolism in medically ill hospitalized elderly cancer patients: a prospective observational study",
abstract = "Purpose: The aim of this study was to estimate the incidence and predictors of venous thromboembolism (VTE) in medically ill hospitalized elderly cancer patients in a single Korean tertiary hospital. Methods: Patients were examined for deep vein thrombosis (DVT) by duplex and color Doppler ultrasonography (DUS) of both legs between days 5 and 14 of their hospital stays. The primary endpoint was the incidence of VTE by day 14, which was determined via a composite of DVT detected by routine DUS and symptomatic VTE. Results: A total of 140 patients with 31 hematologic and 109 nonhematologic malignancies were analyzed. The median age was 73 years, and 45.7{\%} of the patients were female. The median length of hospital stay was 12 days. The modified Padua prediction score (PPS) ≥ 4 was 92.9{\%}. The incidence of VTE by day 14 was 7.1{\%}, including six proximal and four distal DVT cases. Being female, having a length of hospital stay of ≥ 13 days, and having a modified Padua prediction score of ≥ 6 were risk factors of VTE in univariate analysis. The incidence of VTE was 2.3{\%}, 7.3{\%}, and 41.7{\%} in patients with 0–1, 2, and 3 of these risk factors, respectively. Conclusion: The incidence of VTE in medically ill hospitalized elderly cancer patients was lower in Korean patients than in Western patients. However, the risk of VTE in those with more than two risk factors (female, long length of hospitalization, and high PPS) increased considerably, and pharmacologic thromboprophylaxis is warranted in these cases.",
keywords = "Cancer, Elderly, Hospitalized, Risk factors, Venous thromboembolism",
author = "Lee, {Jeong Ok} and Lee, {Ji Yun} and Chun, {Eun Ju} and Sangil Choi and Kim, {Jin Won} and Kim, {Se Hyun} and Kim, {Yu Jung} and Keun-Wook Lee and Kim, {Jee Hyun} and Lee, {Jong Seok} and Bang, {Soo Mee}",
year = "2019",
month = "7",
day = "1",
doi = "10.1007/s00520-018-4537-y",
language = "English",
volume = "27",
pages = "2507--2515",
journal = "Supportive Care in Cancer",
issn = "0941-4355",
publisher = "Springer Verlag",
number = "7",

}

Incidence and predictors of venous thromboembolism in medically ill hospitalized elderly cancer patients : a prospective observational study. / Lee, Jeong Ok; Lee, Ji Yun; Chun, Eun Ju; Choi, Sangil; Kim, Jin Won; Kim, Se Hyun; Kim, Yu Jung; Lee, Keun-Wook; Kim, Jee Hyun; Lee, Jong Seok; Bang, Soo Mee.

In: Supportive Care in Cancer, Vol. 27, No. 7, 01.07.2019, p. 2507-2515.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Incidence and predictors of venous thromboembolism in medically ill hospitalized elderly cancer patients

T2 - a prospective observational study

AU - Lee, Jeong Ok

AU - Lee, Ji Yun

AU - Chun, Eun Ju

AU - Choi, Sangil

AU - Kim, Jin Won

AU - Kim, Se Hyun

AU - Kim, Yu Jung

AU - Lee, Keun-Wook

AU - Kim, Jee Hyun

AU - Lee, Jong Seok

AU - Bang, Soo Mee

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Purpose: The aim of this study was to estimate the incidence and predictors of venous thromboembolism (VTE) in medically ill hospitalized elderly cancer patients in a single Korean tertiary hospital. Methods: Patients were examined for deep vein thrombosis (DVT) by duplex and color Doppler ultrasonography (DUS) of both legs between days 5 and 14 of their hospital stays. The primary endpoint was the incidence of VTE by day 14, which was determined via a composite of DVT detected by routine DUS and symptomatic VTE. Results: A total of 140 patients with 31 hematologic and 109 nonhematologic malignancies were analyzed. The median age was 73 years, and 45.7% of the patients were female. The median length of hospital stay was 12 days. The modified Padua prediction score (PPS) ≥ 4 was 92.9%. The incidence of VTE by day 14 was 7.1%, including six proximal and four distal DVT cases. Being female, having a length of hospital stay of ≥ 13 days, and having a modified Padua prediction score of ≥ 6 were risk factors of VTE in univariate analysis. The incidence of VTE was 2.3%, 7.3%, and 41.7% in patients with 0–1, 2, and 3 of these risk factors, respectively. Conclusion: The incidence of VTE in medically ill hospitalized elderly cancer patients was lower in Korean patients than in Western patients. However, the risk of VTE in those with more than two risk factors (female, long length of hospitalization, and high PPS) increased considerably, and pharmacologic thromboprophylaxis is warranted in these cases.

AB - Purpose: The aim of this study was to estimate the incidence and predictors of venous thromboembolism (VTE) in medically ill hospitalized elderly cancer patients in a single Korean tertiary hospital. Methods: Patients were examined for deep vein thrombosis (DVT) by duplex and color Doppler ultrasonography (DUS) of both legs between days 5 and 14 of their hospital stays. The primary endpoint was the incidence of VTE by day 14, which was determined via a composite of DVT detected by routine DUS and symptomatic VTE. Results: A total of 140 patients with 31 hematologic and 109 nonhematologic malignancies were analyzed. The median age was 73 years, and 45.7% of the patients were female. The median length of hospital stay was 12 days. The modified Padua prediction score (PPS) ≥ 4 was 92.9%. The incidence of VTE by day 14 was 7.1%, including six proximal and four distal DVT cases. Being female, having a length of hospital stay of ≥ 13 days, and having a modified Padua prediction score of ≥ 6 were risk factors of VTE in univariate analysis. The incidence of VTE was 2.3%, 7.3%, and 41.7% in patients with 0–1, 2, and 3 of these risk factors, respectively. Conclusion: The incidence of VTE in medically ill hospitalized elderly cancer patients was lower in Korean patients than in Western patients. However, the risk of VTE in those with more than two risk factors (female, long length of hospitalization, and high PPS) increased considerably, and pharmacologic thromboprophylaxis is warranted in these cases.

KW - Cancer

KW - Elderly

KW - Hospitalized

KW - Risk factors

KW - Venous thromboembolism

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U2 - 10.1007/s00520-018-4537-y

DO - 10.1007/s00520-018-4537-y

M3 - Article

VL - 27

SP - 2507

EP - 2515

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 7

ER -