In vivo proton magnetic resonance spectroscopy of central neurocytomas

Donggyu Kim, Woo Jin Choe, Kee Hyun Chang, In Chan Song, Moon Hee Han, Hee Won Jung, Byung Kyu Cho

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

OBJECTIVE: The authors report on the metabolic features of central neurocytomas observed during in vivo single-voxel proton magnetic resonance spectroscopy. METHODS: Volume-selective single-voxel proton magnetic resonance spectroscopy was performed with a 1.5-T unit using a point-resolved spectroscopy sequence (TR/TE = 2000 ms/135 and 270 ms) to obtain spectra of a single 8-cc voxel. The subjects were five patients in the Department of Neurosurgery of Seoul National University Hospital whose central neurocytomas had been diagnosed histologically. The peak intensities of compounds containing choline (Cho), N-acetylaspartate, creatine/phosphocreatine, and lactate were analyzed. RESULTS: The ratios of Cho to creatine/phosphocreatine and Cho to N-acetylaspartate were significantly higher than ratios in normal brains. A lactate signal was present, and an unidentified signal was also observed at 3.55 ppm, which might have been produced by inositol or glycine. CONCLUSION: A combination of the signal at 3.55 ppm and a prominent Cho peak seems to be a characteristic feature of central neurocytomas. Volume- selective single-voxel proton magnetic resonance spectroscopy could provide additional information to aid in diagnosing this condition.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalNeurosurgery
Volume46
Issue number2
StatePublished - 1 Feb 2000

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Neurocytoma
Choline
Phosphocreatine
Creatine
Lactic Acid
Neurosurgery
Inositol
Glycine
Spectrum Analysis
Proton Magnetic Resonance Spectroscopy
Brain

Keywords

  • Central neurocytoma
  • Choline-containing compounds
  • Inositol + glycine
  • Lactate
  • N-acetylaspartate
  • Proton magnetic resonance spectroscopy

Cite this

Kim, D., Choe, W. J., Chang, K. H., Song, I. C., Han, M. H., Jung, H. W., & Cho, B. K. (2000). In vivo proton magnetic resonance spectroscopy of central neurocytomas. Neurosurgery, 46(2), 329-334.
Kim, Donggyu ; Choe, Woo Jin ; Chang, Kee Hyun ; Song, In Chan ; Han, Moon Hee ; Jung, Hee Won ; Cho, Byung Kyu. / In vivo proton magnetic resonance spectroscopy of central neurocytomas. In: Neurosurgery. 2000 ; Vol. 46, No. 2. pp. 329-334.
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Kim, D, Choe, WJ, Chang, KH, Song, IC, Han, MH, Jung, HW & Cho, BK 2000, 'In vivo proton magnetic resonance spectroscopy of central neurocytomas', Neurosurgery, vol. 46, no. 2, pp. 329-334.

In vivo proton magnetic resonance spectroscopy of central neurocytomas. / Kim, Donggyu; Choe, Woo Jin; Chang, Kee Hyun; Song, In Chan; Han, Moon Hee; Jung, Hee Won; Cho, Byung Kyu.

In: Neurosurgery, Vol. 46, No. 2, 01.02.2000, p. 329-334.

Research output: Contribution to journalArticle

TY - JOUR

T1 - In vivo proton magnetic resonance spectroscopy of central neurocytomas

AU - Kim, Donggyu

AU - Choe, Woo Jin

AU - Chang, Kee Hyun

AU - Song, In Chan

AU - Han, Moon Hee

AU - Jung, Hee Won

AU - Cho, Byung Kyu

PY - 2000/2/1

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N2 - OBJECTIVE: The authors report on the metabolic features of central neurocytomas observed during in vivo single-voxel proton magnetic resonance spectroscopy. METHODS: Volume-selective single-voxel proton magnetic resonance spectroscopy was performed with a 1.5-T unit using a point-resolved spectroscopy sequence (TR/TE = 2000 ms/135 and 270 ms) to obtain spectra of a single 8-cc voxel. The subjects were five patients in the Department of Neurosurgery of Seoul National University Hospital whose central neurocytomas had been diagnosed histologically. The peak intensities of compounds containing choline (Cho), N-acetylaspartate, creatine/phosphocreatine, and lactate were analyzed. RESULTS: The ratios of Cho to creatine/phosphocreatine and Cho to N-acetylaspartate were significantly higher than ratios in normal brains. A lactate signal was present, and an unidentified signal was also observed at 3.55 ppm, which might have been produced by inositol or glycine. CONCLUSION: A combination of the signal at 3.55 ppm and a prominent Cho peak seems to be a characteristic feature of central neurocytomas. Volume- selective single-voxel proton magnetic resonance spectroscopy could provide additional information to aid in diagnosing this condition.

AB - OBJECTIVE: The authors report on the metabolic features of central neurocytomas observed during in vivo single-voxel proton magnetic resonance spectroscopy. METHODS: Volume-selective single-voxel proton magnetic resonance spectroscopy was performed with a 1.5-T unit using a point-resolved spectroscopy sequence (TR/TE = 2000 ms/135 and 270 ms) to obtain spectra of a single 8-cc voxel. The subjects were five patients in the Department of Neurosurgery of Seoul National University Hospital whose central neurocytomas had been diagnosed histologically. The peak intensities of compounds containing choline (Cho), N-acetylaspartate, creatine/phosphocreatine, and lactate were analyzed. RESULTS: The ratios of Cho to creatine/phosphocreatine and Cho to N-acetylaspartate were significantly higher than ratios in normal brains. A lactate signal was present, and an unidentified signal was also observed at 3.55 ppm, which might have been produced by inositol or glycine. CONCLUSION: A combination of the signal at 3.55 ppm and a prominent Cho peak seems to be a characteristic feature of central neurocytomas. Volume- selective single-voxel proton magnetic resonance spectroscopy could provide additional information to aid in diagnosing this condition.

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Kim D, Choe WJ, Chang KH, Song IC, Han MH, Jung HW et al. In vivo proton magnetic resonance spectroscopy of central neurocytomas. Neurosurgery. 2000 Feb 1;46(2):329-334.