In vitro and in vivo evaluations of bioactive poly(ε-caprolactone)- organosiloxane nano-hybrid developed as a novel bone substitute

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We evaluated the cellular behaviors of human bone marrow stromal cells (hBMSCs) on the surface of apatite pre-coated poly(ε-caprolactone)- organosiloxane nano-hybrid material (SiOPCL) and assessed the osteoconductivity of SiOPCL in the diaphyses of the rabbit tibiae. The attachment and proliferation of hBMSCs on both polycaprolactone (PCL) and apatite pre-coated SiOPCL (SiOPCL/HAp) was comparable to those observed on tissue culture plates (TCPs). The alkaline phosphatase activity of hBMSCs on both PCL and SiOPCL/HAp was significantly higher compared with those on the TCPs. There was newly formed bone, together with numerous osteoblasts, along the entire surface of the SiOPCL with in vivo testing. However, we observed severe inflammatory reactions and foreign body responses without evidence of new bone formation after the implantation of PCL. These results demonstrated that SiOPCL had compatible hBMSCs responses and excellent osteoconductivity in vivo.

Original languageEnglish
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages314-317
Number of pages4
Volume2
StatePublished - 1 Oct 2008
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: 1 Jun 20085 Jun 2008

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period1/06/085/06/08

Fingerprint

Bone
Polycaprolactone
Tissue culture
Apatite
Osteoblasts
Hybrid materials
Phosphatases
Testing

Keywords

  • Bioactivity
  • Bone substitute
  • Osteoconduction
  • Polycaprolactone
  • Siloxane

Cite this

Yoo, J. J., Kim, H. J., & Rhee, S. H. (2008). In vitro and in vivo evaluations of bioactive poly(ε-caprolactone)- organosiloxane nano-hybrid developed as a novel bone substitute. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (Vol. 2, pp. 314-317)
Yoo, Jeong Joon ; Kim, Hee Joong ; Rhee, S. H. / In vitro and in vivo evaluations of bioactive poly(ε-caprolactone)- organosiloxane nano-hybrid developed as a novel bone substitute. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. Vol. 2 2008. pp. 314-317
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Yoo, JJ, Kim, HJ & Rhee, SH 2008, In vitro and in vivo evaluations of bioactive poly(ε-caprolactone)- organosiloxane nano-hybrid developed as a novel bone substitute. in Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. vol. 2, pp. 314-317, 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008, Quebec City, QC, United States, 1/06/08.

In vitro and in vivo evaluations of bioactive poly(ε-caprolactone)- organosiloxane nano-hybrid developed as a novel bone substitute. / Yoo, Jeong Joon; Kim, Hee Joong; Rhee, S. H.

Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. Vol. 2 2008. p. 314-317.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Yoo JJ, Kim HJ, Rhee SH. In vitro and in vivo evaluations of bioactive poly(ε-caprolactone)- organosiloxane nano-hybrid developed as a novel bone substitute. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. Vol. 2. 2008. p. 314-317