Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy

Yong Il Kim, Seunggyun Ha, Young So, Won Woo Lee, Seok Soo Byun, Sang Eun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. Methods: Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. Results: The revised equation for improved GFR was GFR(mL/min) = (%renal uptake × 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m 2) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m2; P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m2) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). Conclusions: GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. Key Points: • Measurement of glomerular filtration rate is difficult following nephrectomy. • Measurements can be significantly improved by new renal sctintigraphic methods. • This helps physicians to measure kidney function of patients following nephrectomy. • Management of renal tumour patients should become more effective.

Original languageEnglish
Pages (from-to)413-422
Number of pages10
JournalEuropean Radiology
Volume24
Issue number2
DOIs
StatePublished - 1 Feb 2014

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Technetium Tc 99m Pentetate
Nephrectomy
Glomerular Filtration Rate
Radionuclide Imaging
Edetic Acid
Kidney

Keywords

  • Cr-51 EDTA
  • Gamma camera imaging
  • Glomerular filtration rate
  • Nephrectomy
  • Tc-99m DTPA

Cite this

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title = "Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy",
abstract = "Objective: We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. Methods: Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the {\%}renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. Results: The revised equation for improved GFR was GFR(mL/min) = ({\%}renal uptake × 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m 2) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m2; P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m2) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). Conclusions: GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. Key Points: • Measurement of glomerular filtration rate is difficult following nephrectomy. • Measurements can be significantly improved by new renal sctintigraphic methods. • This helps physicians to measure kidney function of patients following nephrectomy. • Management of renal tumour patients should become more effective.",
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Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy. / Kim, Yong Il; Ha, Seunggyun; So, Young; Lee, Won Woo; Byun, Seok Soo; Kim, Sang Eun.

In: European Radiology, Vol. 24, No. 2, 01.02.2014, p. 413-422.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Improved measurement of the glomerular filtration rate from Tc-99m DTPA scintigraphy in patients following nephrectomy

AU - Kim, Yong Il

AU - Ha, Seunggyun

AU - So, Young

AU - Lee, Won Woo

AU - Byun, Seok Soo

AU - Kim, Sang Eun

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N2 - Objective: We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. Methods: Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. Results: The revised equation for improved GFR was GFR(mL/min) = (%renal uptake × 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m 2) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m2; P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m2) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). Conclusions: GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. Key Points: • Measurement of glomerular filtration rate is difficult following nephrectomy. • Measurements can be significantly improved by new renal sctintigraphic methods. • This helps physicians to measure kidney function of patients following nephrectomy. • Management of renal tumour patients should become more effective.

AB - Objective: We aimed to improve Tc-99m DTPA glomerular filtration rate (GFR) scintigraphy (Gates' method) in a prospective study using Cr-51 EDTA GFR test as a gold standard. Methods: Fifty-seven Tc-99m DTPA GFR scintigrams in 45 subjects (male/female = 33:12, age = 45.9 ± 17.6 years, 14 healthy volunteers and 31 nephrectomised patients) were compared using Cr-51 EDTA GFR tests. Using the %renal uptake of Tc-99m DTPA and Cr-51 EDTA GFR, a revised equation for GFR was established through linear regression analysis. Results: The revised equation for improved GFR was GFR(mL/min) = (%renal uptake × 11.7773) - 0.7354. Gates' original GFRs (70.1 ± 20.5 mL/min/1.73 m 2) were significantly lower than Cr-51 EDTA GFRs (97.0 ± 31.9 mL/min/1.73 m2; P < 0.0001), but the improved GFRs (98.0 ± 26.3 mL/min/1.73 m2) were not different from (P = 0.7360) and had a significant correlation with (r = 0.73, P < 0.0001) the Cr-51 EDTA GFRs. The revised GFR equation effectively demonstrated perioperative GFR changes in kidneys that were operated on and the contralateral kidneys at 3 and 6 months post-partial nephrectomy (n = 25). Conclusions: GFR measurement using Tc-99m DTPA scintigraphy could be significantly improved by a revised equation derived from the comparison with Cr-51 EDTA GFR. Key Points: • Measurement of glomerular filtration rate is difficult following nephrectomy. • Measurements can be significantly improved by new renal sctintigraphic methods. • This helps physicians to measure kidney function of patients following nephrectomy. • Management of renal tumour patients should become more effective.

KW - Cr-51 EDTA

KW - Gamma camera imaging

KW - Glomerular filtration rate

KW - Nephrectomy

KW - Tc-99m DTPA

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