Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance Ca2+-activated K+ channel in Aplysia neuron R15

Yong Lee, Jin Hee Han, Chae Seok Lim, Deok Jin Chang, Yong-Seok Lee, Heun Soh, Chul Seung Park, Bong Kiun Kaang

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

The electrical properties of neurons are produced by the coordinated activity of ion channels. K+ channels play a key role in shaping action potentials and in determining neural firing patterns. Small conductance Ca2+-activated K+ (SKCa) channels are involved in modulating the slow component of afterhyperpolarization (AHP). Here we examine whether rat type 2 SKCa (rSK2) channels can affect the shape of the action potential and the neural firing pattern, by overexpressing rat SK2 channels in Aplysia neuron R15. Our results show that rSK2 overexpression decreased the intra-burst frequency and changed the regular bursting activity of neurons to an irregular bursting or beating pattern in R15. Furthermore, the overexpression of rSK2 channels increased AHP and reduced the duration of the action potential. Thus, our results suggest that ectopic SKCa channels play an important role in regulating the firing pattern and the shape of the action potential.

Original languageEnglish
Pages (from-to)53-57
Number of pages5
JournalNeuroscience Letters
Volume349
Issue number1
DOIs
StatePublished - 25 Sep 2003

Fingerprint

Calcium-Activated Potassium Channels
Aplysia
Action Potentials
Neurons
Ion Channels
Ectopic Gene Expression
rat Kcnn2 protein

Keywords

  • Action potential
  • Afterhyperpolarization
  • Focal epilepsy
  • Gene transfer
  • Parabolic bursting

Cite this

Lee, Yong ; Han, Jin Hee ; Lim, Chae Seok ; Chang, Deok Jin ; Lee, Yong-Seok ; Soh, Heun ; Park, Chul Seung ; Kaang, Bong Kiun. / Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance Ca2+-activated K+ channel in Aplysia neuron R15. In: Neuroscience Letters. 2003 ; Vol. 349, No. 1. pp. 53-57.
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abstract = "The electrical properties of neurons are produced by the coordinated activity of ion channels. K+ channels play a key role in shaping action potentials and in determining neural firing patterns. Small conductance Ca2+-activated K+ (SKCa) channels are involved in modulating the slow component of afterhyperpolarization (AHP). Here we examine whether rat type 2 SKCa (rSK2) channels can affect the shape of the action potential and the neural firing pattern, by overexpressing rat SK2 channels in Aplysia neuron R15. Our results show that rSK2 overexpression decreased the intra-burst frequency and changed the regular bursting activity of neurons to an irregular bursting or beating pattern in R15. Furthermore, the overexpression of rSK2 channels increased AHP and reduced the duration of the action potential. Thus, our results suggest that ectopic SKCa channels play an important role in regulating the firing pattern and the shape of the action potential.",
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Impairment of a parabolic bursting rhythm by the ectopic expression of a small conductance Ca2+-activated K+ channel in Aplysia neuron R15. / Lee, Yong; Han, Jin Hee; Lim, Chae Seok; Chang, Deok Jin; Lee, Yong-Seok; Soh, Heun; Park, Chul Seung; Kaang, Bong Kiun.

In: Neuroscience Letters, Vol. 349, No. 1, 25.09.2003, p. 53-57.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Chang, Deok Jin

AU - Lee, Yong-Seok

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AU - Park, Chul Seung

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