Impact on survival of regular postoperative surveillance for patients with early breast cancer

Ji Yun Lee, Sung Hee Lim, Min Young Lee, Haesu Kim, Moonjin Kim, Sungmin Kim, Hyun Ae Jung, Insuk Sohn, Won Ho Gil, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam, Jin Seok Ahn, Young Hyuck Im, Yeon Hee Park

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Abstract

Purpose The purpose of this study is to evaluate the role of regular postoperative surveillance to improve the prognosis of patients with breast cancer after curative surgery. Materials and Methods We retrospectively analyzed the medical records of 4,119 patients who received curative surgery for breast cancer at Samsung Medical Center between January 2000 and September 2008. Patients were divided into two groups (group I, regular postoperative surveillance; group II, control group) according to their post-therapy follow-up status for the first 5 years after surgery. Results Among the 3,770 patients selected for inclusion, groups I and II contained 3,300 (87%) and 470 (13%) patients, respectively. The recurrence rates at 5 years for groups I and II were 10.6% and 16.4%, respectively (hazard ratio, 0.85; 95% confidence interval [CI], 0.67 to 1.09; p=0.197). The 10-year mortality cumulative rates were 8.8% for group I and 25.4% for group II (hazard ratio, 0.28; 95% CI, 0.22 to 0.35; p < 0.001). In multivariate analysis for recurrence-free survival (RFS), age over 40 years (p < 0.001), histologic grade 1 (p < 0.001), and pathologic stage I (p < 0.001) were associated with longer RFS but not with follow- up status. Multivariate analysis for overall survival (OS) revealed that patients in group I showed significantly improved OS (hazard ratio, 0.29; 95% CI, 0.23 to 0.37; p < 0.001). Additionally, age over 40 years, histologic grade I, and pathologic stage I were independent prognostic factors for OS. Conclusion Regular follow-up for patients with breast cancer after primary surgery resulted in clinically significant improvements in patient OS.

Original languageEnglish
Pages (from-to)765-773
Number of pages9
JournalCancer Research and Treatment
Volume47
Issue number4
DOIs
StatePublished - 2015

Keywords

  • Breast neoplasms
  • Epidemiology
  • Recurrence

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    Lee, J. Y., Lim, S. H., Lee, M. Y., Kim, H., Kim, M., Kim, S., Jung, H. A., Sohn, I., Gil, W. H., Lee, J. E., Kim, S. W., Nam, S. J., Ahn, J. S., Im, Y. H., & Park, Y. H. (2015). Impact on survival of regular postoperative surveillance for patients with early breast cancer. Cancer Research and Treatment, 47(4), 765-773. https://doi.org/10.4143/crt.2014.168