Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation

Hyeon Jin Cho, Dong Yeop Shin, Jin Hee Kim, Ji Yeon Bae, Kyung Hun Lee, Cha Ja See, Naeyu Kim, Eun Kyung Park, Eun Kyung Ra, Jong Eun Lee, Yun Chul Hong, Hyun Kyung Kim, Sung Sup Park, Sung Soo Yoon, Dong Soon Lee, Kyou Sup Han, Myoung Hee Park, Seonyang Park, Byoung Kook Kim, Inho Kim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We hypothesized that polymorphisms of the vitamin D receptor (VDR) gene might affect clinical outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Three VDR gene polymorphisms (BsmI G>A, ApaI G>T, and TaqI T>C) were genotyped in 147 patients who underwent HLA-matched sibling allogeneic HSCT. Frequencies of infection, graft-vs.-host disease (GVHD), overall survival (OS), and disease-free survival (DFS) were compared according to genotypes and haplotypes. Infection and acute GVHD had trends to be less frequent in patients with ApaI TT genotype than non-TT genotypes (p=0.061 and p=0.059, respectively). For TaqI genotypes, there were no statistical differences in frequency of infection and acute GVHD (p=0.84 and p=0.30, respectively), but TC genotype was associated with longer OS and DFS than TT genotype (p=0.022 and p=0.038, respectively). In the ApaI-TaqI haplotype analysis, patients with TC haplotype had significantly longer OS and DFS than those without TC haplotype (p=0.022 and p=0.038, respectively). In multivariable analysis, TaqI genotype and ApaI-TaqI haplotype of recipients were independent prognostic factors for both OS and DFS. This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA-matched HSCT.

Original languageEnglish
Pages (from-to)476-483
Number of pages8
JournalClinical Transplantation
Volume26
Issue number3
DOIs
StatePublished - 1 May 2012

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Calcitriol Receptors
Hematopoietic Stem Cell Transplantation
Siblings
Genotype
Haplotypes
Genes
Disease-Free Survival
Survival
Infection
Transplants

Keywords

  • Polymorphism
  • Stem cell transplantation
  • Vitamin D receptor

Cite this

Cho, Hyeon Jin ; Shin, Dong Yeop ; Kim, Jin Hee ; Bae, Ji Yeon ; Lee, Kyung Hun ; See, Cha Ja ; Kim, Naeyu ; Park, Eun Kyung ; Ra, Eun Kyung ; Lee, Jong Eun ; Hong, Yun Chul ; Kim, Hyun Kyung ; Park, Sung Sup ; Yoon, Sung Soo ; Lee, Dong Soon ; Han, Kyou Sup ; Park, Myoung Hee ; Park, Seonyang ; Kim, Byoung Kook ; Kim, Inho. / Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation. In: Clinical Transplantation. 2012 ; Vol. 26, No. 3. pp. 476-483.
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Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation. / Cho, Hyeon Jin; Shin, Dong Yeop; Kim, Jin Hee; Bae, Ji Yeon; Lee, Kyung Hun; See, Cha Ja; Kim, Naeyu; Park, Eun Kyung; Ra, Eun Kyung; Lee, Jong Eun; Hong, Yun Chul; Kim, Hyun Kyung; Park, Sung Sup; Yoon, Sung Soo; Lee, Dong Soon; Han, Kyou Sup; Park, Myoung Hee; Park, Seonyang; Kim, Byoung Kook; Kim, Inho.

In: Clinical Transplantation, Vol. 26, No. 3, 01.05.2012, p. 476-483.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation

AU - Cho, Hyeon Jin

AU - Shin, Dong Yeop

AU - Kim, Jin Hee

AU - Bae, Ji Yeon

AU - Lee, Kyung Hun

AU - See, Cha Ja

AU - Kim, Naeyu

AU - Park, Eun Kyung

AU - Ra, Eun Kyung

AU - Lee, Jong Eun

AU - Hong, Yun Chul

AU - Kim, Hyun Kyung

AU - Park, Sung Sup

AU - Yoon, Sung Soo

AU - Lee, Dong Soon

AU - Han, Kyou Sup

AU - Park, Myoung Hee

AU - Park, Seonyang

AU - Kim, Byoung Kook

AU - Kim, Inho

PY - 2012/5/1

Y1 - 2012/5/1

N2 - We hypothesized that polymorphisms of the vitamin D receptor (VDR) gene might affect clinical outcomes of allogeneic hematopoietic stem cell transplantation (HSCT). Three VDR gene polymorphisms (BsmI G>A, ApaI G>T, and TaqI T>C) were genotyped in 147 patients who underwent HLA-matched sibling allogeneic HSCT. Frequencies of infection, graft-vs.-host disease (GVHD), overall survival (OS), and disease-free survival (DFS) were compared according to genotypes and haplotypes. Infection and acute GVHD had trends to be less frequent in patients with ApaI TT genotype than non-TT genotypes (p=0.061 and p=0.059, respectively). For TaqI genotypes, there were no statistical differences in frequency of infection and acute GVHD (p=0.84 and p=0.30, respectively), but TC genotype was associated with longer OS and DFS than TT genotype (p=0.022 and p=0.038, respectively). In the ApaI-TaqI haplotype analysis, patients with TC haplotype had significantly longer OS and DFS than those without TC haplotype (p=0.022 and p=0.038, respectively). In multivariable analysis, TaqI genotype and ApaI-TaqI haplotype of recipients were independent prognostic factors for both OS and DFS. This study suggests that the genotype and haplotype of VDR in recipient might be associated with clinical outcome of sibling HLA-matched HSCT.

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KW - Polymorphism

KW - Stem cell transplantation

KW - Vitamin D receptor

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