Impact of Gleason score on biochemical recurrence in patients with pT3aN0/Nx prostate cancer with positive surgical margins: a multicenter study from the Prostate Cancer Research Committee

Wan Song, Dong Hyeon Lee, Hwang Gyun Jeon, Byong Chang Jeong, Seong Il Seo, Hyun Moo Lee, Han Yong Choi, Jong Wook Kim, Sang Chul Lee, Seok Soo Byun, Chang Wook Jeong, Cheol Kwak, Jin Seon Cho, Hanjong Ahn, Seong Soo Jeon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Oncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients. Methods: A retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified. Kaplan–Meier survival analysis was used to illustrate BCR-free survival (BFS) and Cox proportional hazard models were applied to identify factors predicting BCR. Results: During the mean follow-up period of 63.9 months, BCR was identified in 274 (34.5%) patients. The 5-year BFS was 56.6% in all patients. In multivariate analysis, pathologic GS was the only significant prognostic factor for BCR in patients with pT3aN0/Nx PCa with PSM (GS 6 vs. GS 7 (3 + 4), P = 0.047; vs. GS 7 (4 + 3), P = 0.007, and vs. GS 8–10, P < 0.001). When patients were stratified according to GS, 5-year BFS was 78.6% in GS 6, 66.2% in GS 7 (3 + 4), 51.1% in GS 7 (4 + 3) and 35.5% in GS 8–10. Conclusions: In patients with pT3aN0/Nx with PSM after RP, pathologic GS is the sole independent predictor for risk stratification of BCR. These findings might be used to determine the risk and timing of BCR and to help counsel patients regarding treatment strategy and prognosis of disease on an individual basis.

Original languageEnglish
Pages (from-to)2393-2400
Number of pages8
JournalJournal of Cancer Research and Clinical Oncology
Volume143
Issue number11
DOIs
StatePublished - 1 Nov 2017

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Neoplasm Grading
Multicenter Studies
Prostatic Neoplasms
Recurrence
Research
Prostatectomy
Survival
Margins of Excision
Survival Analysis
Proportional Hazards Models
Multivariate Analysis
Retrospective Studies

Keywords

  • Biochemical recurrence
  • Gleason score
  • Positive surgical margin
  • Prognostic factor
  • Prostate cancer

Cite this

Song, Wan ; Lee, Dong Hyeon ; Jeon, Hwang Gyun ; Jeong, Byong Chang ; Seo, Seong Il ; Lee, Hyun Moo ; Choi, Han Yong ; Kim, Jong Wook ; Lee, Sang Chul ; Byun, Seok Soo ; Jeong, Chang Wook ; Kwak, Cheol ; Cho, Jin Seon ; Ahn, Hanjong ; Jeon, Seong Soo. / Impact of Gleason score on biochemical recurrence in patients with pT3aN0/Nx prostate cancer with positive surgical margins : a multicenter study from the Prostate Cancer Research Committee. In: Journal of Cancer Research and Clinical Oncology. 2017 ; Vol. 143, No. 11. pp. 2393-2400.
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title = "Impact of Gleason score on biochemical recurrence in patients with pT3aN0/Nx prostate cancer with positive surgical margins: a multicenter study from the Prostate Cancer Research Committee",
abstract = "Purpose: Oncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients. Methods: A retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified. Kaplan–Meier survival analysis was used to illustrate BCR-free survival (BFS) and Cox proportional hazard models were applied to identify factors predicting BCR. Results: During the mean follow-up period of 63.9 months, BCR was identified in 274 (34.5{\%}) patients. The 5-year BFS was 56.6{\%} in all patients. In multivariate analysis, pathologic GS was the only significant prognostic factor for BCR in patients with pT3aN0/Nx PCa with PSM (GS 6 vs. GS 7 (3 + 4), P = 0.047; vs. GS 7 (4 + 3), P = 0.007, and vs. GS 8–10, P < 0.001). When patients were stratified according to GS, 5-year BFS was 78.6{\%} in GS 6, 66.2{\%} in GS 7 (3 + 4), 51.1{\%} in GS 7 (4 + 3) and 35.5{\%} in GS 8–10. Conclusions: In patients with pT3aN0/Nx with PSM after RP, pathologic GS is the sole independent predictor for risk stratification of BCR. These findings might be used to determine the risk and timing of BCR and to help counsel patients regarding treatment strategy and prognosis of disease on an individual basis.",
keywords = "Biochemical recurrence, Gleason score, Positive surgical margin, Prognostic factor, Prostate cancer",
author = "Wan Song and Lee, {Dong Hyeon} and Jeon, {Hwang Gyun} and Jeong, {Byong Chang} and Seo, {Seong Il} and Lee, {Hyun Moo} and Choi, {Han Yong} and Kim, {Jong Wook} and Lee, {Sang Chul} and Byun, {Seok Soo} and Jeong, {Chang Wook} and Cheol Kwak and Cho, {Jin Seon} and Hanjong Ahn and Jeon, {Seong Soo}",
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Impact of Gleason score on biochemical recurrence in patients with pT3aN0/Nx prostate cancer with positive surgical margins : a multicenter study from the Prostate Cancer Research Committee. / Song, Wan; Lee, Dong Hyeon; Jeon, Hwang Gyun; Jeong, Byong Chang; Seo, Seong Il; Lee, Hyun Moo; Choi, Han Yong; Kim, Jong Wook; Lee, Sang Chul; Byun, Seok Soo; Jeong, Chang Wook; Kwak, Cheol; Cho, Jin Seon; Ahn, Hanjong; Jeon, Seong Soo.

In: Journal of Cancer Research and Clinical Oncology, Vol. 143, No. 11, 01.11.2017, p. 2393-2400.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Impact of Gleason score on biochemical recurrence in patients with pT3aN0/Nx prostate cancer with positive surgical margins

T2 - a multicenter study from the Prostate Cancer Research Committee

AU - Song, Wan

AU - Lee, Dong Hyeon

AU - Jeon, Hwang Gyun

AU - Jeong, Byong Chang

AU - Seo, Seong Il

AU - Lee, Hyun Moo

AU - Choi, Han Yong

AU - Kim, Jong Wook

AU - Lee, Sang Chul

AU - Byun, Seok Soo

AU - Jeong, Chang Wook

AU - Kwak, Cheol

AU - Cho, Jin Seon

AU - Ahn, Hanjong

AU - Jeon, Seong Soo

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Purpose: Oncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients. Methods: A retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified. Kaplan–Meier survival analysis was used to illustrate BCR-free survival (BFS) and Cox proportional hazard models were applied to identify factors predicting BCR. Results: During the mean follow-up period of 63.9 months, BCR was identified in 274 (34.5%) patients. The 5-year BFS was 56.6% in all patients. In multivariate analysis, pathologic GS was the only significant prognostic factor for BCR in patients with pT3aN0/Nx PCa with PSM (GS 6 vs. GS 7 (3 + 4), P = 0.047; vs. GS 7 (4 + 3), P = 0.007, and vs. GS 8–10, P < 0.001). When patients were stratified according to GS, 5-year BFS was 78.6% in GS 6, 66.2% in GS 7 (3 + 4), 51.1% in GS 7 (4 + 3) and 35.5% in GS 8–10. Conclusions: In patients with pT3aN0/Nx with PSM after RP, pathologic GS is the sole independent predictor for risk stratification of BCR. These findings might be used to determine the risk and timing of BCR and to help counsel patients regarding treatment strategy and prognosis of disease on an individual basis.

AB - Purpose: Oncologic outcomes of patients with pT3aN0/Nx prostate cancer (PCa) with positive surgical margins (PSM) after radical prostatectomy (RP) are heterogeneous. We investigated the impact of Gleason score (GS) on biochemical recurrence (BCR) in these patients. Methods: A retrospective, multicenter study was performed on 795 patients with pT3aN0/Nx PCa with PSM after RP between January 2006 and December 2014. Clinicopathologic characteristics of patients were examined and onset of BCR was identified. Kaplan–Meier survival analysis was used to illustrate BCR-free survival (BFS) and Cox proportional hazard models were applied to identify factors predicting BCR. Results: During the mean follow-up period of 63.9 months, BCR was identified in 274 (34.5%) patients. The 5-year BFS was 56.6% in all patients. In multivariate analysis, pathologic GS was the only significant prognostic factor for BCR in patients with pT3aN0/Nx PCa with PSM (GS 6 vs. GS 7 (3 + 4), P = 0.047; vs. GS 7 (4 + 3), P = 0.007, and vs. GS 8–10, P < 0.001). When patients were stratified according to GS, 5-year BFS was 78.6% in GS 6, 66.2% in GS 7 (3 + 4), 51.1% in GS 7 (4 + 3) and 35.5% in GS 8–10. Conclusions: In patients with pT3aN0/Nx with PSM after RP, pathologic GS is the sole independent predictor for risk stratification of BCR. These findings might be used to determine the risk and timing of BCR and to help counsel patients regarding treatment strategy and prognosis of disease on an individual basis.

KW - Biochemical recurrence

KW - Gleason score

KW - Positive surgical margin

KW - Prognostic factor

KW - Prostate cancer

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U2 - 10.1007/s00432-017-2502-7

DO - 10.1007/s00432-017-2502-7

M3 - Article

C2 - 28823006

AN - SCOPUS:85027862709

VL - 143

SP - 2393

EP - 2400

JO - Journal of cancer research and clinical oncology

JF - Journal of cancer research and clinical oncology

SN - 0171-5216

IS - 11

ER -