Impact of DBPon all-cause and cardiovascular mortality: Results fromthe NationalHealth and Nutrition Examination survey,1999^2014

Eunjin Bae, Michael V. Rocco, Jeonghwan Lee, Jae Yoon Park, Yong Chul Kim, Kyung Don Yoo, Eun Young Kim, Dong Jun Park, Chun Soo Lim, Yon Su Kim, Jung Pyo Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Hypertension is common and has a significant effect on cardiovascular morbidity and death. However, despite the development of several guidelines to manage SBP, there is little research or guidance on the evaluation and management of DBP or isolated diastolic hypertension (IDH). Method: To determine the association of DBP with allcause and cardiovascular mortality, we used NHANES data from 1999 to 2014 and included adults aged at least 18 years. The relationship between DBP, IDH and all-cause, cardiovascular mortality was evaluated. Results: Of the 35 109 participants, all-cause death occurred in 10.6%, and cardiovascular death occurred in 2.1% over a median follow-up of 7.2 years. Multivariate Cox regression analysis revealed that the risk of all-cause mortality was significantly higher in the lowest (_56.9 mmHg) DBP groups than in the reference group (DBP 74-76.9 mmHg). However, the risk of cardiovascular mortality was significantly higher in the lowest and highest (_83 mmHg) DBP group than in the reference group. The risk of all-cause mortality was higher for most groups with SBP at least 140mmHg than for the reference group with DBP 74-76.9mmHg and SBP 100-139.9 mmHg. Both the 2018 ESC/NICE and the 2017 AHA/ACC-defined IDH was not significantly associated with all-cause mortality. Conclusion: DBP and all-cause mortality had an inverse relationship, whereas DBP and cardiovascular mortality had a U-shaped relationship, with the DBP reference group having the lowest risk for all-cause and cardiovascular mortality. There was no significant relationship between IDH and death.

Original languageEnglish
Pages (from-to)108-116
Number of pages9
JournalJournal of hypertension
Volume40
Issue number1
DOIs
StatePublished - 1 Jan 2022

Keywords

  • Diastolic blood pressure
  • Isolated diastolic hypertension
  • Mortality

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