Impact of bevacizumab and secondary cytoreductive surgery on survival outcomes in platinum-sensitive relapsed ovarian clear cell carcinoma: A multicenter study in Korea

Se Ik Kim, Ji Hyun Kim, Joseph J. Noh, Seung Ho Kim, Tae Eun Kim, Kidong Kim, Jeong Yeol Park, Myong Cheol Lim, Jeong Won Lee, Jae Weon Kim

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study investigated survival outcomes for platinum-sensitive relapsed ovarian clear cell carcinoma (OCCC) by treatment method. Methods: OCCC patients with platinum-sensitive recurrence that received secondary treatment at five institutions between July 2007 and June 2021 were included. Patient characteristics and survival outcomes were compared according to the use of bevacizumab (BEV) during second-line chemotherapy and secondary cytoreductive surgery (CRS). Results: 138 patients were included. The BEV (n = 36) and non-BEV (n = 102) groups had similar initial FIGO stages and proportions of secondary CRS. The BEV group showed improved progression-free survival (PFS; median, 15.4 vs. 7.5 months; P = 0.042) and overall survival (OS; P = 0.043) compared to the non-BEV group. In multivariate analyses, BEV was identified as an independent prognostic factor for PFS (adjusted hazard ratio [aHR], 0.571; 95% confidence interval [CI], 0.354–0.921; P = 0.022) and OS (aHR, 0.435; 95%CI, 0.195–0.970; P = 0.042). The secondary CRS group (n = 42) had early-stage disease at diagnosis more frequently (P = 0.009) and multi-site metastasis (P < 0.001) at recurrence less frequently than the no surgery group (n = 96). The secondary CRS group showed significantly better PFS (median, 33.7 vs. 7.2 months; P < 0.001) and OS (P < 0.001). Secondary CRS was associated with a significantly improved PFS (aHR, 0.297; 95% CI, 0.183–0.481; P < 0.001) and OS (aHR, 0.276; 95% CI, 0.133–0.576; P = 0.001). The BEV and non-BEV groups showed similar PFS and OS among the patients who underwent secondary CRS. In contrast, the BEV group showed improved PFS and OS among patients who did not undergo surgery. Conclusions: The use of BEV during second-line chemotherapy and secondary CRS may improve PFS and OS in patients with platinum-sensitive relapsed OCCC. Further prospective studies are warranted.

Original languageEnglish
Pages (from-to)444-452
Number of pages9
JournalGynecologic Oncology
Volume166
Issue number3
DOIs
StatePublished - Sep 2022

Keywords

  • Bevacizumab
  • Clear cell carcinoma
  • Ovarian cancer
  • Recurrence
  • Surgery
  • Survival

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