Immunological reactions on H. pylori infection

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

1 Citation (Scopus)

Abstract

An immune network that responds to bacteria as a mucous membrane defense factor is called gut-associated lymphoid tissue (GALT), which is made up of distinctive tissues of B cell, T cell, and phagocytes. The purpose of GALT is to maintain stomach homeostasis via interaction between immune and nonimmune mechanisms. Actually stomach immune mechanism is mostly about Helicobacter pylori (H. pylori). Long-term H. pylori proliferation indicates failure of gastric immune mechanisms that causes chronic H. pylori inflammation, and various diseases emerge as a result. H. pylori delicately regulate innate and adaptive immunities to evade from host immunity. Especially, H. pylori disrupt T-cell activity such as Th1/ Th2 immunological reaction balance. Th1 produces cytokines like interferon-y and interleukin (IL)-2, and Th2 produces cytokines like IL-4, IL-5, IL-10, and IL-13 and engages with differentiation and activation of B cell. Finally it causes gastritis, peptic ulcer, and mucosa-associated lymphoid tissue (MALT) lymphoma and increases risk of gastric cancer.

Original languageEnglish
Title of host publicationHelicobacter pylori
PublisherSpringer Singapore
Pages35-52
Number of pages18
ISBN (Electronic)9789812877062
ISBN (Print)9789812877055
DOIs
StatePublished - 16 Jun 2016

Fingerprint

Helicobacter Infections
Helicobacter pylori
Stomach
Lymphoid Tissue
B-Lymphocytes
Cytokines
T-Lymphocytes
Marginal Zone B-Cell Lymphoma
Interleukin-13
Interleukin-5
Adaptive Immunity
Gastritis
Phagocytes
Peptic Ulcer
Innate Immunity
Interleukin-4
Interleukin-10
Interferons
Stomach Neoplasms
Interleukin-2

Keywords

  • Gut-associated lymphoid tissue
  • Helicobacter pylori
  • Immunity
  • T helper cell

Cite this

Kim, N. (2016). Immunological reactions on H. pylori infection. In Helicobacter pylori (pp. 35-52). Springer Singapore. https://doi.org/10.1007/978-981-287-706-2_3
Kim, Nayoung. / Immunological reactions on H. pylori infection. Helicobacter pylori. Springer Singapore, 2016. pp. 35-52
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Kim, N 2016, Immunological reactions on H. pylori infection. in Helicobacter pylori. Springer Singapore, pp. 35-52. https://doi.org/10.1007/978-981-287-706-2_3

Immunological reactions on H. pylori infection. / Kim, Nayoung.

Helicobacter pylori. Springer Singapore, 2016. p. 35-52.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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AB - An immune network that responds to bacteria as a mucous membrane defense factor is called gut-associated lymphoid tissue (GALT), which is made up of distinctive tissues of B cell, T cell, and phagocytes. The purpose of GALT is to maintain stomach homeostasis via interaction between immune and nonimmune mechanisms. Actually stomach immune mechanism is mostly about Helicobacter pylori (H. pylori). Long-term H. pylori proliferation indicates failure of gastric immune mechanisms that causes chronic H. pylori inflammation, and various diseases emerge as a result. H. pylori delicately regulate innate and adaptive immunities to evade from host immunity. Especially, H. pylori disrupt T-cell activity such as Th1/ Th2 immunological reaction balance. Th1 produces cytokines like interferon-y and interleukin (IL)-2, and Th2 produces cytokines like IL-4, IL-5, IL-10, and IL-13 and engages with differentiation and activation of B cell. Finally it causes gastritis, peptic ulcer, and mucosa-associated lymphoid tissue (MALT) lymphoma and increases risk of gastric cancer.

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Kim N. Immunological reactions on H. pylori infection. In Helicobacter pylori. Springer Singapore. 2016. p. 35-52 https://doi.org/10.1007/978-981-287-706-2_3