Immunohistochemical and molecular characteristics of follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma

Hye Sook Min, Gheeyoung Choe, Nam Yun Cho, Gyeonghoon Kang, Seong Hoe Park, So Yeon Park

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2 Citations (Scopus)

Abstract

Background: Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs) have not yet been established. The aim of this study is to determine immunohistochemical and molecular characteristics of FTN-INPTCs. Methods: We investigated immunohistochemical features (galectin-3, HBME-1, CK19, fibronectin-1, CITED1), BRAF V600E mutation and RASSF1A promoter methylation status in 30 FTN-INPTC cases, along with 26 FVPTCs, 21 follicular adenomas (FAs) and 14 nodular hyperplasias (NHs). Results: Expression of galectin-3, HBME-1, CK19 and CITED1 was significantly higher in FTN-INPTCs than in FAs or NHs, but expression of galectin-3, CK19 and fibronectin-1 was lower in FTN-INPTCs than in FVPTCs. The BRAF V600E mutation was not detected in the benign nodules or FTN-INPTCs, whereas 57% of FVPTCs had the mutation. RASSF1A promoter methylation was higher in FTN-INPTCs than in benign nodules but there was no difference between FTN-INPTCs and FVPTCs. Conclusions: Our results represent the borderline immunohistochemical and molecular characteristics of FTN-INPTC. We conclude that FTN-INPTC is an intermediate lesion between a benign nodule and a FVPTC, and that it is pathogenetically related to FVPTC.

Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalKorean Journal of Pathology
Volume43
Issue number6
DOIs
StatePublished - 1 Dec 2009

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Thyroid Nodule
Factor IX
Galectin 3
Fibronectins
Adenoma
Methylation
Mutation
Hyperplasia
Papillary Thyroid cancer

Keywords

  • Carcinoma
  • Papillary
  • Thyroid gland
  • Thyroid neoplasms

Cite this

@article{24c8602b6fc24c3ca043d4f4f353eb5e,
title = "Immunohistochemical and molecular characteristics of follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma",
abstract = "Background: Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs) have not yet been established. The aim of this study is to determine immunohistochemical and molecular characteristics of FTN-INPTCs. Methods: We investigated immunohistochemical features (galectin-3, HBME-1, CK19, fibronectin-1, CITED1), BRAF V600E mutation and RASSF1A promoter methylation status in 30 FTN-INPTC cases, along with 26 FVPTCs, 21 follicular adenomas (FAs) and 14 nodular hyperplasias (NHs). Results: Expression of galectin-3, HBME-1, CK19 and CITED1 was significantly higher in FTN-INPTCs than in FAs or NHs, but expression of galectin-3, CK19 and fibronectin-1 was lower in FTN-INPTCs than in FVPTCs. The BRAF V600E mutation was not detected in the benign nodules or FTN-INPTCs, whereas 57{\%} of FVPTCs had the mutation. RASSF1A promoter methylation was higher in FTN-INPTCs than in benign nodules but there was no difference between FTN-INPTCs and FVPTCs. Conclusions: Our results represent the borderline immunohistochemical and molecular characteristics of FTN-INPTC. We conclude that FTN-INPTC is an intermediate lesion between a benign nodule and a FVPTC, and that it is pathogenetically related to FVPTC.",
keywords = "Carcinoma, Papillary, Thyroid gland, Thyroid neoplasms",
author = "Min, {Hye Sook} and Gheeyoung Choe and Cho, {Nam Yun} and Gyeonghoon Kang and Park, {Seong Hoe} and Park, {So Yeon}",
year = "2009",
month = "12",
day = "1",
doi = "10.4132/KoreanJPathol.2009.43.6.495",
language = "English",
volume = "43",
pages = "495--502",
journal = "Korean Journal of Pathology",
issn = "1738-1843",
publisher = "Seoul National University",
number = "6",

}

TY - JOUR

T1 - Immunohistochemical and molecular characteristics of follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma

AU - Min, Hye Sook

AU - Choe, Gheeyoung

AU - Cho, Nam Yun

AU - Kang, Gyeonghoon

AU - Park, Seong Hoe

AU - Park, So Yeon

PY - 2009/12/1

Y1 - 2009/12/1

N2 - Background: Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs) have not yet been established. The aim of this study is to determine immunohistochemical and molecular characteristics of FTN-INPTCs. Methods: We investigated immunohistochemical features (galectin-3, HBME-1, CK19, fibronectin-1, CITED1), BRAF V600E mutation and RASSF1A promoter methylation status in 30 FTN-INPTC cases, along with 26 FVPTCs, 21 follicular adenomas (FAs) and 14 nodular hyperplasias (NHs). Results: Expression of galectin-3, HBME-1, CK19 and CITED1 was significantly higher in FTN-INPTCs than in FAs or NHs, but expression of galectin-3, CK19 and fibronectin-1 was lower in FTN-INPTCs than in FVPTCs. The BRAF V600E mutation was not detected in the benign nodules or FTN-INPTCs, whereas 57% of FVPTCs had the mutation. RASSF1A promoter methylation was higher in FTN-INPTCs than in benign nodules but there was no difference between FTN-INPTCs and FVPTCs. Conclusions: Our results represent the borderline immunohistochemical and molecular characteristics of FTN-INPTC. We conclude that FTN-INPTC is an intermediate lesion between a benign nodule and a FVPTC, and that it is pathogenetically related to FVPTC.

AB - Background: Follicular patterned thyroid nodules with incomplete nuclear features of papillary thyroid carcinoma (FTN-INPTCs) are difficult to diagnose, and their biological behavior and association with follicular variants of PTC (FVPTCs) have not yet been established. The aim of this study is to determine immunohistochemical and molecular characteristics of FTN-INPTCs. Methods: We investigated immunohistochemical features (galectin-3, HBME-1, CK19, fibronectin-1, CITED1), BRAF V600E mutation and RASSF1A promoter methylation status in 30 FTN-INPTC cases, along with 26 FVPTCs, 21 follicular adenomas (FAs) and 14 nodular hyperplasias (NHs). Results: Expression of galectin-3, HBME-1, CK19 and CITED1 was significantly higher in FTN-INPTCs than in FAs or NHs, but expression of galectin-3, CK19 and fibronectin-1 was lower in FTN-INPTCs than in FVPTCs. The BRAF V600E mutation was not detected in the benign nodules or FTN-INPTCs, whereas 57% of FVPTCs had the mutation. RASSF1A promoter methylation was higher in FTN-INPTCs than in benign nodules but there was no difference between FTN-INPTCs and FVPTCs. Conclusions: Our results represent the borderline immunohistochemical and molecular characteristics of FTN-INPTC. We conclude that FTN-INPTC is an intermediate lesion between a benign nodule and a FVPTC, and that it is pathogenetically related to FVPTC.

KW - Carcinoma

KW - Papillary

KW - Thyroid gland

KW - Thyroid neoplasms

UR - http://www.scopus.com/inward/record.url?scp=77951166456&partnerID=8YFLogxK

U2 - 10.4132/KoreanJPathol.2009.43.6.495

DO - 10.4132/KoreanJPathol.2009.43.6.495

M3 - Article

AN - SCOPUS:77951166456

VL - 43

SP - 495

EP - 502

JO - Korean Journal of Pathology

JF - Korean Journal of Pathology

SN - 1738-1843

IS - 6

ER -