Immunoglobulin g4-related disease mimicking unresectable gallbladder cancer

Sang Hyub Lee, Yoon Suk Lee, Min Geun Lee, Seung June Lee, Jin Hyeok Hwang, Eun Shin, Yoon Jin Lee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Immunoglobulin G4 (IgG4)-related disease is a novel disease entity that can involve diverse organs, causing specific diseases, including autoimmune pancreatitis, sclerosing cholangitis, cholecystitis, inflammatory aortic aneurysm, and inflammatory pseudotumor. IgG4-related disease is characterized by elevated serum IgG4 concentrations, abundant IgG4 lymphoplasmacytic infiltration, and dramatic steroid responses. It is clinically important to differentiate this rare disease from primary sclerosing cholangitis and cholangiocarcinoma, because the treatment and prognosis of these two diseases are completely different. However, the preoperative diagnosis is challenging, and the disease is frequently misdiagnosed. If the serum level of IgG4 is within the normal range, the diagnosis of IgG4-related disease is more difficult. This article reports on a 59-year-old man with IgG4-related disease mimicking unresectable gallbladder cancer with normal serum IgG4 concentrations. (Gut Liver 2013;7:616-620).

Original languageEnglish
Pages (from-to)616-620
Number of pages5
JournalGut and Liver
Volume7
Issue number5
DOIs
StatePublished - 1 Sep 2013

Fingerprint

Gallbladder Neoplasms
Immunoglobulins
Sclerosing Cholangitis
Serum
Plasma Cell Granuloma
Cholecystitis
Cholangiocarcinoma
Aortic Aneurysm
Rare Diseases
Diagnostic Errors
Pancreatitis
Autoimmune Diseases
Reference Values
Steroids
Liver

Keywords

  • Cholangitis, sclerosing
  • Cholecystitis
  • Gallbladder neoplasms
  • Immunoglobuin G

Cite this

Lee, Sang Hyub ; Lee, Yoon Suk ; Lee, Min Geun ; Lee, Seung June ; Hwang, Jin Hyeok ; Shin, Eun ; Lee, Yoon Jin. / Immunoglobulin g4-related disease mimicking unresectable gallbladder cancer. In: Gut and Liver. 2013 ; Vol. 7, No. 5. pp. 616-620.
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Immunoglobulin g4-related disease mimicking unresectable gallbladder cancer. / Lee, Sang Hyub; Lee, Yoon Suk; Lee, Min Geun; Lee, Seung June; Hwang, Jin Hyeok; Shin, Eun; Lee, Yoon Jin.

In: Gut and Liver, Vol. 7, No. 5, 01.09.2013, p. 616-620.

Research output: Contribution to journalArticle

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