Il-7ralow cd8+ t cells from healthy individuals are anergic with defective glycolysis

Ji Hyun Sim, Jin Hee Kim, Ae Kyung Park, Jeeyun Lee, Kyoung Mee Kim, Hyun Mu Shin, Minji Kim, Kyungho Choi, Eun Young Choi, Insoo Kang, Dong Sup Lee, Hang Rae Kim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Effector memory (EM) CD8+ T cells expressing lower levels of IL-7R a (IL-7Ralow) from healthy individuals are partly compromised in vitro, but the identity of these cells has remained unclear. In this study, we demonstrate that human IL-7Ralow EM CD8+ T cells are naturally occurring anergic cells in vivo and impaired in proliferation and IL-2 production but competent in IFN-g and TNF-a production, a state that can be restored by IL-2 stimulation. IL-7Ralow EM CD8+ T cells show decreased expression of GATA3 and c-MYC and are defective in metabolic reprogramming toward glycolysis, a process required for the proliferation of T cells. However, IL-7Ralow EM CD8+ T cells can proliferate with TCR stimulation in the presence of IL-2 and IL-15, suggesting that these cells can be restored to normality or increased activity by inflammatory conditions and may serve as a reservoir for functional immunity.

Original languageEnglish
Pages (from-to)2968-2978
Number of pages11
JournalJournal of Immunology
Issue number11
StatePublished - 1 Dec 2020


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