IFN-γ inhibits basal and α-MSH-induced melanogenesis

Jinyoung Son, Misun Kim, Ilo Jou, Kyoung Chan Park, Hee Young Kang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Inflammatory cytokines are closely related to pigmentary changes. In this study, the effects of IFN-γ on melanogenesis were investigated. IFN-γ inhibits basal and α-MSH-induced melanogenesis in B16 melanoma cells and normal human melanocytes. MITF mRNA and protein expressions were significantly inhibited in response to IFN-γ. IFN-γ inhibited CREB binding to the MITF promoter but did not affect CREB phosphorylation. Instead, IFN-γ inhibited the association of CBP and CREB through the increased association between CREB binding protein (CBP) and STAT1. These findings suggest that IFN-γ inhibits both basal and α-MSH-induced melanogenesis by inhibiting MITF expression. The inhibitory action of IFN-γ in α-MSH-induced melanogenesis is likely to be associated with the sequestration of CBP via the association between CBP and STAT1. These data suggest that IFN-γ plays a role in controlling inflammation- or UV-induced pigmentary changes.

Original languageEnglish
Pages (from-to)201-208
Number of pages8
JournalPigment Cell and Melanoma Research
Volume27
Issue number2
DOIs
StatePublished - 1 Mar 2014

Fingerprint

CREB-Binding Protein
Melanocyte-Stimulating Hormones
Association reactions
Microphthalmia-Associated Transcription Factor
Experimental Melanomas
Phosphorylation
Melanocytes
Cytokines
Inflammation
Messenger RNA
Proteins

Keywords

  • IFN-γ
  • Melanogenesis
  • α-MSH

Cite this

Son, Jinyoung ; Kim, Misun ; Jou, Ilo ; Park, Kyoung Chan ; Kang, Hee Young. / IFN-γ inhibits basal and α-MSH-induced melanogenesis. In: Pigment Cell and Melanoma Research. 2014 ; Vol. 27, No. 2. pp. 201-208.
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abstract = "Inflammatory cytokines are closely related to pigmentary changes. In this study, the effects of IFN-γ on melanogenesis were investigated. IFN-γ inhibits basal and α-MSH-induced melanogenesis in B16 melanoma cells and normal human melanocytes. MITF mRNA and protein expressions were significantly inhibited in response to IFN-γ. IFN-γ inhibited CREB binding to the MITF promoter but did not affect CREB phosphorylation. Instead, IFN-γ inhibited the association of CBP and CREB through the increased association between CREB binding protein (CBP) and STAT1. These findings suggest that IFN-γ inhibits both basal and α-MSH-induced melanogenesis by inhibiting MITF expression. The inhibitory action of IFN-γ in α-MSH-induced melanogenesis is likely to be associated with the sequestration of CBP via the association between CBP and STAT1. These data suggest that IFN-γ plays a role in controlling inflammation- or UV-induced pigmentary changes.",
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IFN-γ inhibits basal and α-MSH-induced melanogenesis. / Son, Jinyoung; Kim, Misun; Jou, Ilo; Park, Kyoung Chan; Kang, Hee Young.

In: Pigment Cell and Melanoma Research, Vol. 27, No. 2, 01.03.2014, p. 201-208.

Research output: Contribution to journalArticle

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AB - Inflammatory cytokines are closely related to pigmentary changes. In this study, the effects of IFN-γ on melanogenesis were investigated. IFN-γ inhibits basal and α-MSH-induced melanogenesis in B16 melanoma cells and normal human melanocytes. MITF mRNA and protein expressions were significantly inhibited in response to IFN-γ. IFN-γ inhibited CREB binding to the MITF promoter but did not affect CREB phosphorylation. Instead, IFN-γ inhibited the association of CBP and CREB through the increased association between CREB binding protein (CBP) and STAT1. These findings suggest that IFN-γ inhibits both basal and α-MSH-induced melanogenesis by inhibiting MITF expression. The inhibitory action of IFN-γ in α-MSH-induced melanogenesis is likely to be associated with the sequestration of CBP via the association between CBP and STAT1. These data suggest that IFN-γ plays a role in controlling inflammation- or UV-induced pigmentary changes.

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