Identification of novel SNPs in the interleukin 6 receptor gene (IL6R).

Lyoung Hyo Kim, Hyo Suk Lee, Yoon Jun Kim, Ji Hyun Jung, Jun Yeun Kim, Byung Lae Park, Hyoung Doo Shin

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The human interleukin-6 receptor (IL6R) is responsible for signal transduction of IL6 that might have associations with immune diseases and various infectious diseases. We have sequenced all 10 exons including the putative splicing site to identify single nucleotide polymorphisms in IL6R. Seven novel single nucleotide polymorphisms (SNPs) were identified; one SNP in the promoter region (-183G>A), one synonymous SNP in exon 2 (24013G>A: Ala31Ala), one non-synonymous SNP in exon 9 (48892A>C: Asp358Ala) and four in introns (29753A>C, 42700T>C, 48869T>A and 59818C>T). The frequencies of each SNP in the Korean population (n=300) were 0.48 (-183 G>A), 0.13 (24013 G>A), 0.41 (29753A>C), 0.41 (42700T>C), 0.1 (48869T>A), 0.42 (48892A>C), and 0.07 (59818C>T), respectively. Haplotypes and their frequencies were estimated by the EM algorithm. Linkage disequilibrium coefficients (/D'/) between each SNP pair were also calculated. The information on SNPs and haplotypes in IL6R would be useful for genetic studies of this gene.

Original languageEnglish
Pages (from-to)450-451
Number of pages2
JournalHuman Mutation
Issue number4
StatePublished - 1 Jan 2003

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Kim, L. H., Lee, H. S., Kim, Y. J., Jung, J. H., Kim, J. Y., Park, B. L., & Shin, H. D. (2003). Identification of novel SNPs in the interleukin 6 receptor gene (IL6R). Human Mutation, 21(4), 450-451.