Abstract
Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions. Based on information as to which types of genes are controlled by HIF-1, it appears that HIF-1 provides pathological tissues with survival in hypoxic regions or angiogenic activity. Therefore, HIF-1 inhibitors could be useful as therapeutic agents for various diseases associated with the over-activation of HIF-1, such as cancers, cardiovascular remodeling, preeclamsia, and other angiogenesis-related diseases. In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 221-232 |
| Number of pages | 12 |
| Journal | Journal of Pharmacological Sciences |
| Volume | 94 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2004 |
Keywords
- HIF competitor
- HIF inhibitor
- HIF-related disease
- Hypoxia-inducible factor (HIF)
