Hypoxia-Inducible Factor 1-Related Diseases and Prospective Therapeutic Tools

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Abstract

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. HIF-1 regulates the expressions of the proteins that increase oxygen delivery, which enables cells to survive in oxygen-deficient conditions. Based on information as to which types of genes are controlled by HIF-1, it appears that HIF-1 provides pathological tissues with survival in hypoxic regions or angiogenic activity. Therefore, HIF-1 inhibitors could be useful as therapeutic agents for various diseases associated with the over-activation of HIF-1, such as cancers, cardiovascular remodeling, preeclamsia, and other angiogenesis-related diseases. In this review, we summarize the oxygen-dependent and -independent regulation of HIF-1 and introduce prospective HIF-1 inhibitors that might be useful in the treatment of HIF-1-related diseases.

Original languageEnglish
Pages (from-to)221-232
Number of pages12
JournalJournal of Pharmacological Sciences
Volume94
Issue number3
DOIs
StatePublished - Mar 2004

Keywords

  • HIF competitor
  • HIF inhibitor
  • HIF-related disease
  • Hypoxia-inducible factor (HIF)

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