How cancer cells remodel lipid metabolism: strategies targeting transcription factors

Do Won Jeong, Seulbee Lee, Yang Sook Chun

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Reprogramming of lipid metabolism has received increasing recognition as a hallmark of cancer cells because lipid dysregulation and the alteration of related enzyme profiles are closely correlated with oncogenic signals and malignant phenotypes, such as metastasis and therapeutic resistance. In this review, we describe recent findings that support the importance of lipids, as well as the transcription factors involved in cancer lipid metabolism. With recent advances in transcription factor analysis, including computer-modeling techniques, transcription factors are emerging as central players in cancer biology. Considering the limited number and the crucial role of transcription factors associated with lipid rewiring in cancers, transcription factor targeting is a promising potential strategy for cancer therapy.

Original languageEnglish
Article number163
JournalLipids in Health and Disease
Volume20
Issue number1
DOIs
StatePublished - Dec 2021

Keywords

  • Cancer
  • Lipid metabolism
  • Transcription factor

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