HLA-B51 Carriers are Susceptible to Ocular Symptoms of Behçet Disease and the Association between the Two Becomes Stronger towards the East along the Silk Road: A Literature Survey

Yukihiro Horie, Akira Meguro, Tohru Ohta, Eun Bong Lee, Kenichi Namba, Kazuomi Mizuuchi, Daiju Iwata, Nobuhisa Mizuki, Masao Ota, Hidetoshi Inoko, Susumu Ishida, Shigeaki Ohno, Nobuyoshi Kitaichi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: Behçet disease (BD) is predominantly found between East Asia and the Mediterranean basin along the historic Silk Road. HLA-B51 is known to be strongly associated with BD. We investigated the association between HLA-B51 and the ocular manifestations of BD among various ethnic groups. Methods: A literature survey was conducted, and 18 articles written in English were reviewed. Results: A strong correlation was found between HLA-B51 and ocular lesions in the entire cohort discussed in the reviewed articles (OR = 1.76, p = 0.000057). HLA-B51 was shown to have a strong association with ocular manifestations of BD patients in East-Eurasian (OR = 2.40, p = 0.0030) and Middle-Eurasian (OR = 1.87, p = 0.0045), but not in West-Eurasian (OR = 1.28, p = 0.35) areas. This correlation seemed to become stronger towards the east. Conclusions: A meta-analysis showed that the correlation became stronger towards the east along the Silk Road. The study results may facilitate understanding of the etiology and characteristics of BD.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalOcular Immunology and Inflammation
Volume25
Issue number1
DOIs
StatePublished - 2 Jan 2017

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HLA-B51 Antigen
Silk
Eye Manifestations
Far East
Ethnic Groups
Meta-Analysis
Surveys and Questionnaires

Keywords

  • BD
  • Silk Road disease
  • meta-analysis
  • ocular manifestation

Cite this

Horie, Yukihiro ; Meguro, Akira ; Ohta, Tohru ; Lee, Eun Bong ; Namba, Kenichi ; Mizuuchi, Kazuomi ; Iwata, Daiju ; Mizuki, Nobuhisa ; Ota, Masao ; Inoko, Hidetoshi ; Ishida, Susumu ; Ohno, Shigeaki ; Kitaichi, Nobuyoshi. / HLA-B51 Carriers are Susceptible to Ocular Symptoms of Behçet Disease and the Association between the Two Becomes Stronger towards the East along the Silk Road : A Literature Survey. In: Ocular Immunology and Inflammation. 2017 ; Vol. 25, No. 1. pp. 37-40.
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HLA-B51 Carriers are Susceptible to Ocular Symptoms of Behçet Disease and the Association between the Two Becomes Stronger towards the East along the Silk Road : A Literature Survey. / Horie, Yukihiro; Meguro, Akira; Ohta, Tohru; Lee, Eun Bong; Namba, Kenichi; Mizuuchi, Kazuomi; Iwata, Daiju; Mizuki, Nobuhisa; Ota, Masao; Inoko, Hidetoshi; Ishida, Susumu; Ohno, Shigeaki; Kitaichi, Nobuyoshi.

In: Ocular Immunology and Inflammation, Vol. 25, No. 1, 02.01.2017, p. 37-40.

Research output: Contribution to journalArticle

TY - JOUR

T1 - HLA-B51 Carriers are Susceptible to Ocular Symptoms of Behçet Disease and the Association between the Two Becomes Stronger towards the East along the Silk Road

T2 - A Literature Survey

AU - Horie, Yukihiro

AU - Meguro, Akira

AU - Ohta, Tohru

AU - Lee, Eun Bong

AU - Namba, Kenichi

AU - Mizuuchi, Kazuomi

AU - Iwata, Daiju

AU - Mizuki, Nobuhisa

AU - Ota, Masao

AU - Inoko, Hidetoshi

AU - Ishida, Susumu

AU - Ohno, Shigeaki

AU - Kitaichi, Nobuyoshi

PY - 2017/1/2

Y1 - 2017/1/2

N2 - Purpose: Behçet disease (BD) is predominantly found between East Asia and the Mediterranean basin along the historic Silk Road. HLA-B51 is known to be strongly associated with BD. We investigated the association between HLA-B51 and the ocular manifestations of BD among various ethnic groups. Methods: A literature survey was conducted, and 18 articles written in English were reviewed. Results: A strong correlation was found between HLA-B51 and ocular lesions in the entire cohort discussed in the reviewed articles (OR = 1.76, p = 0.000057). HLA-B51 was shown to have a strong association with ocular manifestations of BD patients in East-Eurasian (OR = 2.40, p = 0.0030) and Middle-Eurasian (OR = 1.87, p = 0.0045), but not in West-Eurasian (OR = 1.28, p = 0.35) areas. This correlation seemed to become stronger towards the east. Conclusions: A meta-analysis showed that the correlation became stronger towards the east along the Silk Road. The study results may facilitate understanding of the etiology and characteristics of BD.

AB - Purpose: Behçet disease (BD) is predominantly found between East Asia and the Mediterranean basin along the historic Silk Road. HLA-B51 is known to be strongly associated with BD. We investigated the association between HLA-B51 and the ocular manifestations of BD among various ethnic groups. Methods: A literature survey was conducted, and 18 articles written in English were reviewed. Results: A strong correlation was found between HLA-B51 and ocular lesions in the entire cohort discussed in the reviewed articles (OR = 1.76, p = 0.000057). HLA-B51 was shown to have a strong association with ocular manifestations of BD patients in East-Eurasian (OR = 2.40, p = 0.0030) and Middle-Eurasian (OR = 1.87, p = 0.0045), but not in West-Eurasian (OR = 1.28, p = 0.35) areas. This correlation seemed to become stronger towards the east. Conclusions: A meta-analysis showed that the correlation became stronger towards the east along the Silk Road. The study results may facilitate understanding of the etiology and characteristics of BD.

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