High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus

Sung Hee Choi, Heon Kwak Soo, Byung Soo Youn, Soo Lim, Young Joo Park, Hyewon Lee, Namseok Lee, Min Cho Young, Kyu Lee Hong, Young Bum Kim, Kyong Soo Park, Hak Chul Jang

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Context: Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. Objective: We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. Design, Setting, Patients, and Main Outcome Measures: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT afterGDM(GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). Results: Plasma RBP4 concentration was significantly higher in women with GDM-DM, GDM-IGT, and GDM-NGT than in those with NP. RBP4 concentration correlated positively with TTR concentration; fasting plasma glucose, insulin, and triglyceride concentrations; blood pressure; abdominal fat area; and homeostasis model assessment of insulin resistance. Plasma TTR concentration was elevated in women with GDM-DM compared with other groups. In contrast, adiponectin concentration was lowest in the GDM-DM group and correlated inversely with parameters of insulin resistance. Resistin concentration was higher only in the GDM-NGT and GDM-IGT groups, whereas leptin did not differ between groups. Plasma RBP4 and adiponectin concentrations were inversely correlated. Conclusions: The severity of glucose intolerance inwomenwithpGDMis associated with high RBP4 and low adiponectin concentrations.

Original languageEnglish
Pages (from-to)3142-3148
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume93
Issue number8
DOIs
StatePublished - Aug 2008

Fingerprint

Plasma Retinol-Binding Proteins
Glucose Intolerance
Gestational Diabetes
Adiponectin
Medical problems
Plasmas
Glucose
Prealbumin
Insulated gate bipolar transistors (IGBT)
Retinol-Binding Proteins
Adipokines
Type 2 Diabetes Mellitus
Insulin Resistance
Insulin
Homeostasis
Resistin
Abdominal Fat
Leptin
Blood pressure
Fasting

Cite this

@article{024c217b68e54173bfda898793632e9c,
title = "High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus",
abstract = "Context: Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. Objective: We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. Design, Setting, Patients, and Main Outcome Measures: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT afterGDM(GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). Results: Plasma RBP4 concentration was significantly higher in women with GDM-DM, GDM-IGT, and GDM-NGT than in those with NP. RBP4 concentration correlated positively with TTR concentration; fasting plasma glucose, insulin, and triglyceride concentrations; blood pressure; abdominal fat area; and homeostasis model assessment of insulin resistance. Plasma TTR concentration was elevated in women with GDM-DM compared with other groups. In contrast, adiponectin concentration was lowest in the GDM-DM group and correlated inversely with parameters of insulin resistance. Resistin concentration was higher only in the GDM-NGT and GDM-IGT groups, whereas leptin did not differ between groups. Plasma RBP4 and adiponectin concentrations were inversely correlated. Conclusions: The severity of glucose intolerance inwomenwithpGDMis associated with high RBP4 and low adiponectin concentrations.",
author = "Choi, {Sung Hee} and Soo, {Heon Kwak} and Youn, {Byung Soo} and Soo Lim and Park, {Young Joo} and Hyewon Lee and Namseok Lee and Young, {Min Cho} and Hong, {Kyu Lee} and Kim, {Young Bum} and Park, {Kyong Soo} and Jang, {Hak Chul}",
year = "2008",
month = "8",
doi = "10.1210/jc.2007-1755",
language = "English",
volume = "93",
pages = "3142--3148",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus

AU - Choi, Sung Hee

AU - Soo, Heon Kwak

AU - Youn, Byung Soo

AU - Lim, Soo

AU - Park, Young Joo

AU - Lee, Hyewon

AU - Lee, Namseok

AU - Young, Min Cho

AU - Hong, Kyu Lee

AU - Kim, Young Bum

AU - Park, Kyong Soo

AU - Jang, Hak Chul

PY - 2008/8

Y1 - 2008/8

N2 - Context: Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. Objective: We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. Design, Setting, Patients, and Main Outcome Measures: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT afterGDM(GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). Results: Plasma RBP4 concentration was significantly higher in women with GDM-DM, GDM-IGT, and GDM-NGT than in those with NP. RBP4 concentration correlated positively with TTR concentration; fasting plasma glucose, insulin, and triglyceride concentrations; blood pressure; abdominal fat area; and homeostasis model assessment of insulin resistance. Plasma TTR concentration was elevated in women with GDM-DM compared with other groups. In contrast, adiponectin concentration was lowest in the GDM-DM group and correlated inversely with parameters of insulin resistance. Resistin concentration was higher only in the GDM-NGT and GDM-IGT groups, whereas leptin did not differ between groups. Plasma RBP4 and adiponectin concentrations were inversely correlated. Conclusions: The severity of glucose intolerance inwomenwithpGDMis associated with high RBP4 and low adiponectin concentrations.

AB - Context: Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. Objective: We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. Design, Setting, Patients, and Main Outcome Measures: We measured the plasma concentrations of retinol-binding protein-4 (RBP4), transthyretin (TTR), and adiponectin and metabolic parameters in four groups of women who exhibited normal glucose tolerance (NGT) during a previous pregnancy (NP, n = 17), NGT afterGDM(GDM-NGT, n = 72), impaired glucose tolerance after GDM (GDM-IGT, n = 60), and type 2 diabetes after GDM (GDM-DM, n = 8). Results: Plasma RBP4 concentration was significantly higher in women with GDM-DM, GDM-IGT, and GDM-NGT than in those with NP. RBP4 concentration correlated positively with TTR concentration; fasting plasma glucose, insulin, and triglyceride concentrations; blood pressure; abdominal fat area; and homeostasis model assessment of insulin resistance. Plasma TTR concentration was elevated in women with GDM-DM compared with other groups. In contrast, adiponectin concentration was lowest in the GDM-DM group and correlated inversely with parameters of insulin resistance. Resistin concentration was higher only in the GDM-NGT and GDM-IGT groups, whereas leptin did not differ between groups. Plasma RBP4 and adiponectin concentrations were inversely correlated. Conclusions: The severity of glucose intolerance inwomenwithpGDMis associated with high RBP4 and low adiponectin concentrations.

UR - http://www.scopus.com/inward/record.url?scp=49249135177&partnerID=8YFLogxK

U2 - 10.1210/jc.2007-1755

DO - 10.1210/jc.2007-1755

M3 - Article

C2 - 18492757

AN - SCOPUS:49249135177

VL - 93

SP - 3142

EP - 3148

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 8

ER -