High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis

Seok Jin Choi, Yoon Ho Hong, Sung Min Kim, Je Young Shin, Young Ju Suh, Jung Joon Sung

Research output: Contribution to journalArticle

Abstract

The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.

Original languageEnglish
Article number428
JournalScientific Reports
Volume10
Issue number1
DOIs
StatePublished - 1 Dec 2020

Fingerprint

Amyotrophic Lateral Sclerosis
Neutrophils
Lymphocytes
Survival
Age of Onset
Tertiary Care Centers
Survival Rate
Regression Analysis

Cite this

@article{89ac655a72c4457195a50d75db928e90,
title = "High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis",
abstract = "The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.",
author = "Choi, {Seok Jin} and Hong, {Yoon Ho} and Kim, {Sung Min} and Shin, {Je Young} and Suh, {Young Ju} and Sung, {Jung Joon}",
year = "2020",
month = "12",
day = "1",
doi = "10.1038/s41598-019-57366-y",
language = "English",
volume = "10",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis. / Choi, Seok Jin; Hong, Yoon Ho; Kim, Sung Min; Shin, Je Young; Suh, Young Ju; Sung, Jung Joon.

In: Scientific Reports, Vol. 10, No. 1, 428, 01.12.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis

AU - Choi, Seok Jin

AU - Hong, Yoon Ho

AU - Kim, Sung Min

AU - Shin, Je Young

AU - Suh, Young Ju

AU - Sung, Jung Joon

PY - 2020/12/1

Y1 - 2020/12/1

N2 - The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.

AB - The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.

UR - http://www.scopus.com/inward/record.url?scp=85077941444&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-57366-y

DO - 10.1038/s41598-019-57366-y

M3 - Article

C2 - 31949271

AN - SCOPUS:85077941444

VL - 10

JO - Scientific reports

JF - Scientific reports

SN - 2045-2322

IS - 1

M1 - 428

ER -