TY - JOUR
T1 - High burden of cerebral white matter lesion in 9 Asian cities
AU - Lam, Bonnie Yin Ka
AU - Yiu, Brian
AU - Ampil, Encarnita
AU - Chen, Christopher Li Hsian
AU - Dikot, Yustiani
AU - Dominguez, Jacqueline C.
AU - Ganeshbhai, Patel Vishal
AU - Hilal, Saima
AU - Kandiah, Nagaendran
AU - Kim, Sang Yun
AU - Lee, Jun Young
AU - Ong, Anam Paulus
AU - Senanarong, Vorapun
AU - Leung, Kam Tat
AU - Wang, Huali
AU - Yang, Yuan Han
AU - Yong, Tingting
AU - Arshad, Faheem
AU - Alladi, Suvarna
AU - Wong, Samuel
AU - Ko, Ho
AU - Lau, Alexander Yuk Lun
AU - Mok, Vincent Chung Tong
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Age-related white matter lesion (WML) is considered a manifestation of sporadic cerebral small vessel disease and an important pathological substrate for dementia. Asia is notable for its large population with a looming dementia epidemic. Yet, the burden of WML and its associated risk factors across different Asian societies are unknown. Subjects from 9 Asian cities (Bangkok, Bandung, Beijing, Bengaluru, Hong Kong, Kaohsiung, Manila, Seoul, and Singapore) were recruited (n = 5701) and classified into (i) stroke/transient ischemic attack (TIA), (ii) Alzheimer’s disease (AD)/mild cognitive impairment (MCI), or (iii) control groups. Data on vascular risk factors and cognitive performance were collected. The severity of WML was visually rated on MRI or CT. The prevalence of moderate-to-severe WML was the highest in subjects with stroke/TIA (43.3%). Bandung Indonesia showed the highest prevalence of WML, adjusted for age, sex, education, disease groups, and imaging modality. Hypertension and hyperlipidemia were significant risk factors for WML, and WML was negatively associated with MMSE in all groups. WML is highly prevalent in Asia and is associated with increasing age, hypertension, hyperlipidemia, and worse cognitive performance. Concerted efforts to prevent WML will alleviate the huge dementia burden in the rapidly aging Asian societies.
AB - Age-related white matter lesion (WML) is considered a manifestation of sporadic cerebral small vessel disease and an important pathological substrate for dementia. Asia is notable for its large population with a looming dementia epidemic. Yet, the burden of WML and its associated risk factors across different Asian societies are unknown. Subjects from 9 Asian cities (Bangkok, Bandung, Beijing, Bengaluru, Hong Kong, Kaohsiung, Manila, Seoul, and Singapore) were recruited (n = 5701) and classified into (i) stroke/transient ischemic attack (TIA), (ii) Alzheimer’s disease (AD)/mild cognitive impairment (MCI), or (iii) control groups. Data on vascular risk factors and cognitive performance were collected. The severity of WML was visually rated on MRI or CT. The prevalence of moderate-to-severe WML was the highest in subjects with stroke/TIA (43.3%). Bandung Indonesia showed the highest prevalence of WML, adjusted for age, sex, education, disease groups, and imaging modality. Hypertension and hyperlipidemia were significant risk factors for WML, and WML was negatively associated with MMSE in all groups. WML is highly prevalent in Asia and is associated with increasing age, hypertension, hyperlipidemia, and worse cognitive performance. Concerted efforts to prevent WML will alleviate the huge dementia burden in the rapidly aging Asian societies.
UR - http://www.scopus.com/inward/record.url?scp=85107213249&partnerID=8YFLogxK
U2 - 10.1038/s41598-021-90746-x
DO - 10.1038/s41598-021-90746-x
M3 - Article
C2 - 34078946
AN - SCOPUS:85107213249
VL - 11
JO - Scientific reports
JF - Scientific reports
SN - 2045-2322
IS - 1
M1 - 11587
ER -