Hepatic Stiffness Using Shear Wave Elastography and the Related Factors for a Fontan Circulation

Seong Ook Kim, Sangyun Lee, So Ick Jang, Soo Jin Park, Hye Won Kwon, Seong Ho Kim, Chang Ha Lee, Eun Seok Choi, Seong Kyu Cho, Sun Hwa Hong, Yang Min Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hepatic problems related to a Fontan circulation have been highlighted and elastography using ultrasound is a non-invasive tool that can measure the severity of hepatic stiffness. We investigated the hepatic stiffness using shear wave elastography (SWE) and related factors in patients with a Fontan circulation. This study enrolled 64 patients with a Fontan circulation who underwent cardiac catheterization and abdominal ultrasound from 2011 to 2015. The correlation between the laboratory tests, hemodynamic factors by cardiac catheterization, and SWE was evaluated. The patients were classified into non-cirrhotic level (≥ 2.0 m/s) and cirrhotic level (< 2.0 m/s) groups by the SWE value. The mean age was 17.6 years and the mean duration after the Fontan operation was 12.1 years. The mean value of SWE in patients (1.95 m/s) was higher than the normal (< 1.3 m/s). The SWE was higher in patients without than those with a fenestration (2.03 vs. 1.75 m/s, P = 0.003). In a multiple regression analysis between SWE and other factors, the CVP, fenestration, and lipoprotein Apo B had a significant correlation. In a multivariate analysis of cirrhotic level group, the CVP was the only significant factor. The hepatic stiffness had significantly progressed in most patients with a Fontan circulation. A low CVP and Fontan circulation with a fenestration might reduce the progression of the hepatic stiffness.

Original languageEnglish
Pages (from-to)57-65
Number of pages9
JournalPediatric Cardiology
Volume39
Issue number1
DOIs
StatePublished - 1 Jan 2018

Fingerprint

Elasticity Imaging Techniques
Liver
Cardiac Catheterization
Fontan Procedure
Apolipoproteins B
Lipoproteins
Multivariate Analysis
Hemodynamics
Regression Analysis

Keywords

  • Cardiac catheterization
  • Elastography
  • Fontan operation
  • Hepatic stiffness

Cite this

Kim, Seong Ook ; Lee, Sangyun ; Jang, So Ick ; Park, Soo Jin ; Kwon, Hye Won ; Kim, Seong Ho ; Lee, Chang Ha ; Choi, Eun Seok ; Cho, Seong Kyu ; Hong, Sun Hwa ; Kim, Yang Min. / Hepatic Stiffness Using Shear Wave Elastography and the Related Factors for a Fontan Circulation. In: Pediatric Cardiology. 2018 ; Vol. 39, No. 1. pp. 57-65.
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abstract = "Hepatic problems related to a Fontan circulation have been highlighted and elastography using ultrasound is a non-invasive tool that can measure the severity of hepatic stiffness. We investigated the hepatic stiffness using shear wave elastography (SWE) and related factors in patients with a Fontan circulation. This study enrolled 64 patients with a Fontan circulation who underwent cardiac catheterization and abdominal ultrasound from 2011 to 2015. The correlation between the laboratory tests, hemodynamic factors by cardiac catheterization, and SWE was evaluated. The patients were classified into non-cirrhotic level (≥ 2.0 m/s) and cirrhotic level (< 2.0 m/s) groups by the SWE value. The mean age was 17.6 years and the mean duration after the Fontan operation was 12.1 years. The mean value of SWE in patients (1.95 m/s) was higher than the normal (< 1.3 m/s). The SWE was higher in patients without than those with a fenestration (2.03 vs. 1.75 m/s, P = 0.003). In a multiple regression analysis between SWE and other factors, the CVP, fenestration, and lipoprotein Apo B had a significant correlation. In a multivariate analysis of cirrhotic level group, the CVP was the only significant factor. The hepatic stiffness had significantly progressed in most patients with a Fontan circulation. A low CVP and Fontan circulation with a fenestration might reduce the progression of the hepatic stiffness.",
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Kim, SO, Lee, S, Jang, SI, Park, SJ, Kwon, HW, Kim, SH, Lee, CH, Choi, ES, Cho, SK, Hong, SH & Kim, YM 2018, 'Hepatic Stiffness Using Shear Wave Elastography and the Related Factors for a Fontan Circulation', Pediatric Cardiology, vol. 39, no. 1, pp. 57-65. https://doi.org/10.1007/s00246-017-1727-1

Hepatic Stiffness Using Shear Wave Elastography and the Related Factors for a Fontan Circulation. / Kim, Seong Ook; Lee, Sangyun; Jang, So Ick; Park, Soo Jin; Kwon, Hye Won; Kim, Seong Ho; Lee, Chang Ha; Choi, Eun Seok; Cho, Seong Kyu; Hong, Sun Hwa; Kim, Yang Min.

In: Pediatric Cardiology, Vol. 39, No. 1, 01.01.2018, p. 57-65.

Research output: Contribution to journalArticle

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T1 - Hepatic Stiffness Using Shear Wave Elastography and the Related Factors for a Fontan Circulation

AU - Kim, Seong Ook

AU - Lee, Sangyun

AU - Jang, So Ick

AU - Park, Soo Jin

AU - Kwon, Hye Won

AU - Kim, Seong Ho

AU - Lee, Chang Ha

AU - Choi, Eun Seok

AU - Cho, Seong Kyu

AU - Hong, Sun Hwa

AU - Kim, Yang Min

PY - 2018/1/1

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KW - Cardiac catheterization

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