Heart rate variability changes in major depressive disorder during sleep: Fractal index correlates with BDI score during REM sleep

Hyun Bin Kwon, Heenam Yoon, Sang Ho Choi, Jae Won Choi, Yu Jin Lee, Kwang Suk Park

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI). Time- and frequency-domain, and fractal HRV parameters were derived from 5-min electrocardiogram segments during light sleep, deep sleep, rapid eye movement (REM) sleep, and the pre- and post-sleep wake periods. Detrended fluctuation analysis (DFA) alpha-1 values during REM sleep were significantly higher in patients with MDD than in control subjects, and a significant correlation existed between DFA alpha-1 and BDI score in all subjects. DFA alpha-1 was the strongest predictor for the BDI score, along with REM density as a covariate. This study found that compared with controls, patients with MDD show reduced complexity in heart rate during REM sleep, which may represent lower cardiovascular adaptability in these patients, and could lead to cardiac disease. Moreover, DFA alpha-1 values measured during REM sleep may be useful as an indicator for the diagnosis and monitoring of depression.

Original languageEnglish
Pages (from-to)291-298
Number of pages8
JournalPsychiatry Research
Volume271
DOIs
StatePublished - Jan 2019

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Fractals
REM Sleep
Major Depressive Disorder
Sleep
Heart Rate
Depression
Equipment and Supplies
Healthy Volunteers
Polysomnography
Sleep Stages
Autonomic Nervous System
Heart Diseases
Electrocardiography
Body Mass Index
Light

Keywords

  • Autonomic nervous system
  • Detrended fluctuation analysis
  • Nonlinear dynamics

Cite this

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title = "Heart rate variability changes in major depressive disorder during sleep: Fractal index correlates with BDI score during REM sleep",
abstract = "We investigated the relationship between autonomic nervous system activity during each sleep stage and the severity of depressive symptoms in patients with major depressive disorder (MDD) and healthy control subjects. Thirty patients with MDD and thirty healthy control subjects matched for sex, age, and body mass index completed standard overnight polysomnography. Depression severity was assessed using the Beck Depression Inventory (BDI). Time- and frequency-domain, and fractal HRV parameters were derived from 5-min electrocardiogram segments during light sleep, deep sleep, rapid eye movement (REM) sleep, and the pre- and post-sleep wake periods. Detrended fluctuation analysis (DFA) alpha-1 values during REM sleep were significantly higher in patients with MDD than in control subjects, and a significant correlation existed between DFA alpha-1 and BDI score in all subjects. DFA alpha-1 was the strongest predictor for the BDI score, along with REM density as a covariate. This study found that compared with controls, patients with MDD show reduced complexity in heart rate during REM sleep, which may represent lower cardiovascular adaptability in these patients, and could lead to cardiac disease. Moreover, DFA alpha-1 values measured during REM sleep may be useful as an indicator for the diagnosis and monitoring of depression.",
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Heart rate variability changes in major depressive disorder during sleep : Fractal index correlates with BDI score during REM sleep. / Kwon, Hyun Bin; Yoon, Heenam; Choi, Sang Ho; Choi, Jae Won; Lee, Yu Jin; Park, Kwang Suk.

In: Psychiatry Research, Vol. 271, 01.2019, p. 291-298.

Research output: Contribution to journalArticle

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