Head-to-head comparison between biparametric and multiparametric MRI for the diagnosis of prostate cancer

A systematic review and meta-analysis

Research output: Contribution to journalReview articleResearchpeer-review

8 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this study was to perform a systematic review and metaanalysis of a head-to-head comparison between the performance of biparametric MRI (bpMRI; only T2-weighted imaging and DWI) and that of multiparametric MRI (mpMRI; T2-weighted imaging, DWI, dynamic contrast-enhanced MRI) for the diagnosis of prostate cancer. MATERIALS AND METHODS. The PubMed and Embase databases were searched up to November 11, 2017. The search included diagnostic test accuracy studies that compared bpMRI and mpMRI for prostate cancer diagnosis with histopathologic findings from biopsy or radical prostatectomy as the reference standard. Methodologic quality was evaluated with the revised Quality Assessment of Diagnostic Accuracy Studies tool. Sensitivity and specificity were pooled by means of bivariate and hierarchic summary ROC (HSROC) modeling and graphically presented with HSROC plots. Meta-regression analysis and multiple subgroup analyses were used to compare the diagnostic performances of bpMRI and mpMRI. RESULTS. Twenty studies (2142 patients) were included. Pooled sensitivity and specificity were 0.74 (95% CI, 0.66-0.81) and 0.90 (95% CI, 0.86-0.93) for bpMRI and 0.76 (95% CI, 0.69-0.82) and 0.89 (95% CI, 0.85-0.93) for mpMRI. MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity (p = 0.83). In 26 subgroups evaluated on the basis of stratification to clinicopathologic, study, and MRI characteristics, MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity in any subgroup (p = 0.25-0.97). CONCLUSION. A head-to-head comparison showed that the performance of bpMRI was similar to that of mpMRI in the diagnosis of prostate cancer. Consistent results were found in multiple subgroup analyses.

Original languageEnglish
Pages (from-to)W226-W241
JournalAmerican Journal of Roentgenology
Volume211
Issue number5
DOIs
StatePublished - 1 Nov 2018

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Meta-Analysis
Prostatic Neoplasms
Sensitivity and Specificity
Prostatectomy
Routine Diagnostic Tests
PubMed
Regression Analysis
Databases
Biopsy

Keywords

  • MRI
  • biparametric
  • contrast media
  • gadolinium
  • meta-analysis
  • multiparametric
  • prostate cancer

Cite this

@article{7b22b1d6914948ebbef0de126d830c46,
title = "Head-to-head comparison between biparametric and multiparametric MRI for the diagnosis of prostate cancer: A systematic review and meta-analysis",
abstract = "OBJECTIVE. The purpose of this study was to perform a systematic review and metaanalysis of a head-to-head comparison between the performance of biparametric MRI (bpMRI; only T2-weighted imaging and DWI) and that of multiparametric MRI (mpMRI; T2-weighted imaging, DWI, dynamic contrast-enhanced MRI) for the diagnosis of prostate cancer. MATERIALS AND METHODS. The PubMed and Embase databases were searched up to November 11, 2017. The search included diagnostic test accuracy studies that compared bpMRI and mpMRI for prostate cancer diagnosis with histopathologic findings from biopsy or radical prostatectomy as the reference standard. Methodologic quality was evaluated with the revised Quality Assessment of Diagnostic Accuracy Studies tool. Sensitivity and specificity were pooled by means of bivariate and hierarchic summary ROC (HSROC) modeling and graphically presented with HSROC plots. Meta-regression analysis and multiple subgroup analyses were used to compare the diagnostic performances of bpMRI and mpMRI. RESULTS. Twenty studies (2142 patients) were included. Pooled sensitivity and specificity were 0.74 (95{\%} CI, 0.66-0.81) and 0.90 (95{\%} CI, 0.86-0.93) for bpMRI and 0.76 (95{\%} CI, 0.69-0.82) and 0.89 (95{\%} CI, 0.85-0.93) for mpMRI. MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity (p = 0.83). In 26 subgroups evaluated on the basis of stratification to clinicopathologic, study, and MRI characteristics, MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity in any subgroup (p = 0.25-0.97). CONCLUSION. A head-to-head comparison showed that the performance of bpMRI was similar to that of mpMRI in the diagnosis of prostate cancer. Consistent results were found in multiple subgroup analyses.",
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author = "Sungmin Woo and Suh, {Chong Hyun} and Kim, {Sang Youn} and Cho, {Jeong Yeon} and Seunghyup Kim and Moon, {Min Hoan}",
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Head-to-head comparison between biparametric and multiparametric MRI for the diagnosis of prostate cancer : A systematic review and meta-analysis. / Woo, Sungmin; Suh, Chong Hyun; Kim, Sang Youn; Cho, Jeong Yeon; Kim, Seunghyup; Moon, Min Hoan.

In: American Journal of Roentgenology, Vol. 211, No. 5, 01.11.2018, p. W226-W241.

Research output: Contribution to journalReview articleResearchpeer-review

TY - JOUR

T1 - Head-to-head comparison between biparametric and multiparametric MRI for the diagnosis of prostate cancer

T2 - A systematic review and meta-analysis

AU - Woo, Sungmin

AU - Suh, Chong Hyun

AU - Kim, Sang Youn

AU - Cho, Jeong Yeon

AU - Kim, Seunghyup

AU - Moon, Min Hoan

PY - 2018/11/1

Y1 - 2018/11/1

N2 - OBJECTIVE. The purpose of this study was to perform a systematic review and metaanalysis of a head-to-head comparison between the performance of biparametric MRI (bpMRI; only T2-weighted imaging and DWI) and that of multiparametric MRI (mpMRI; T2-weighted imaging, DWI, dynamic contrast-enhanced MRI) for the diagnosis of prostate cancer. MATERIALS AND METHODS. The PubMed and Embase databases were searched up to November 11, 2017. The search included diagnostic test accuracy studies that compared bpMRI and mpMRI for prostate cancer diagnosis with histopathologic findings from biopsy or radical prostatectomy as the reference standard. Methodologic quality was evaluated with the revised Quality Assessment of Diagnostic Accuracy Studies tool. Sensitivity and specificity were pooled by means of bivariate and hierarchic summary ROC (HSROC) modeling and graphically presented with HSROC plots. Meta-regression analysis and multiple subgroup analyses were used to compare the diagnostic performances of bpMRI and mpMRI. RESULTS. Twenty studies (2142 patients) were included. Pooled sensitivity and specificity were 0.74 (95% CI, 0.66-0.81) and 0.90 (95% CI, 0.86-0.93) for bpMRI and 0.76 (95% CI, 0.69-0.82) and 0.89 (95% CI, 0.85-0.93) for mpMRI. MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity (p = 0.83). In 26 subgroups evaluated on the basis of stratification to clinicopathologic, study, and MRI characteristics, MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity in any subgroup (p = 0.25-0.97). CONCLUSION. A head-to-head comparison showed that the performance of bpMRI was similar to that of mpMRI in the diagnosis of prostate cancer. Consistent results were found in multiple subgroup analyses.

AB - OBJECTIVE. The purpose of this study was to perform a systematic review and metaanalysis of a head-to-head comparison between the performance of biparametric MRI (bpMRI; only T2-weighted imaging and DWI) and that of multiparametric MRI (mpMRI; T2-weighted imaging, DWI, dynamic contrast-enhanced MRI) for the diagnosis of prostate cancer. MATERIALS AND METHODS. The PubMed and Embase databases were searched up to November 11, 2017. The search included diagnostic test accuracy studies that compared bpMRI and mpMRI for prostate cancer diagnosis with histopathologic findings from biopsy or radical prostatectomy as the reference standard. Methodologic quality was evaluated with the revised Quality Assessment of Diagnostic Accuracy Studies tool. Sensitivity and specificity were pooled by means of bivariate and hierarchic summary ROC (HSROC) modeling and graphically presented with HSROC plots. Meta-regression analysis and multiple subgroup analyses were used to compare the diagnostic performances of bpMRI and mpMRI. RESULTS. Twenty studies (2142 patients) were included. Pooled sensitivity and specificity were 0.74 (95% CI, 0.66-0.81) and 0.90 (95% CI, 0.86-0.93) for bpMRI and 0.76 (95% CI, 0.69-0.82) and 0.89 (95% CI, 0.85-0.93) for mpMRI. MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity (p = 0.83). In 26 subgroups evaluated on the basis of stratification to clinicopathologic, study, and MRI characteristics, MRI protocol (bpMRI vs mpMRI) was not a significant factor in heterogeneity in any subgroup (p = 0.25-0.97). CONCLUSION. A head-to-head comparison showed that the performance of bpMRI was similar to that of mpMRI in the diagnosis of prostate cancer. Consistent results were found in multiple subgroup analyses.

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KW - contrast media

KW - gadolinium

KW - meta-analysis

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KW - prostate cancer

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