Gut microbiota associations with common diseases and prescription medications in a population-based cohort

Matthew A. Jackson, Serena Verdi, Maria Emanuela Maxan, Cheol Min Shin, Jonas Zierer, Ruth C.E. Bowyer, Tiphaine Martin, Frances M.K. Williams, Cristina Menni, Jordana T. Bell, Tim D. Spector, Claire J. Steves

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

The human gut microbiome has been associated with many health factors but variability between studies limits exploration of effects between them. Gut microbiota profiles are available for >2700 members of the deeply phenotyped TwinsUK cohort, providing a uniform platform for such comparisons. Here, we present gut microbiota association analyses for 38 common diseases and 51 medications within the cohort. We describe several novel associations, highlight associations common across multiple diseases, and determine which diseases and medications have the greatest association with the gut microbiota. These results provide a reference for future studies of the gut microbiome and its role in human health.

Original languageEnglish
Article number2655
JournalNature Communications
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2018

Cite this

Jackson, M. A., Verdi, S., Maxan, M. E., Shin, C. M., Zierer, J., Bowyer, R. C. E., Martin, T., Williams, F. M. K., Menni, C., Bell, J. T., Spector, T. D., & Steves, C. J. (2018). Gut microbiota associations with common diseases and prescription medications in a population-based cohort. Nature Communications, 9(1), [2655]. https://doi.org/10.1038/s41467-018-05184-7