Gradual and stepwise increase of blood pressure in hemorrhagic shock: Mimicking ischemic post-conditioning

Jae-Hyuk Lee, Kyuseok Kim, You Hwan Jo, Kyeong Won Kang, Joong Eui Rhee, Chan Jong Park, Joonghee Kim, Heajin Chung

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Hemorrhagic shock, and subsequent resuscitation leads to global ischemia/reperfusion injury. It may result in multiple organ injury and death. Ischemic post-conditioning has been suggested to reduce organ injury. It may lead to gradual increase in tissue oxygen delivery and tissue acidosis may be reduced gradually. Gradual increase of blood pressure or blood flow in ischemic organs has been reported to decrease tissue injury. We propose that gradual and stepwise increase of blood pressure may decrease tissue injury and mortality in hemorrhagic shock by mimicking ischemic post-conditioning.

Original languageEnglish
Pages (from-to)701-703
Number of pages3
JournalMedical Hypotheses
Volume81
Issue number4
DOIs
StatePublished - 1 Oct 2013

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Ischemic Postconditioning
Hemorrhagic Shock
Blood Pressure
Wounds and Injuries
Multiple Trauma
Acidosis
Reperfusion Injury
Resuscitation
Oxygen
Mortality

Cite this

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abstract = "Hemorrhagic shock, and subsequent resuscitation leads to global ischemia/reperfusion injury. It may result in multiple organ injury and death. Ischemic post-conditioning has been suggested to reduce organ injury. It may lead to gradual increase in tissue oxygen delivery and tissue acidosis may be reduced gradually. Gradual increase of blood pressure or blood flow in ischemic organs has been reported to decrease tissue injury. We propose that gradual and stepwise increase of blood pressure may decrease tissue injury and mortality in hemorrhagic shock by mimicking ischemic post-conditioning.",
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Gradual and stepwise increase of blood pressure in hemorrhagic shock : Mimicking ischemic post-conditioning. / Lee, Jae-Hyuk; Kim, Kyuseok; Jo, You Hwan; Kang, Kyeong Won; Rhee, Joong Eui; Park, Chan Jong; Kim, Joonghee; Chung, Heajin.

In: Medical Hypotheses, Vol. 81, No. 4, 01.10.2013, p. 701-703.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gradual and stepwise increase of blood pressure in hemorrhagic shock

T2 - Mimicking ischemic post-conditioning

AU - Lee, Jae-Hyuk

AU - Kim, Kyuseok

AU - Jo, You Hwan

AU - Kang, Kyeong Won

AU - Rhee, Joong Eui

AU - Park, Chan Jong

AU - Kim, Joonghee

AU - Chung, Heajin

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