Genetic variants in interleukin-2 and risk of lymphoma among children in Korea

Nan Song, Sohee Han, Kyoung Mu Lee, Ji Yeob Choi, Sue K. Park, Sujee Jeon, Yunhee Lee, Hyo Seop Ahn, Hee Young Shin, Hyoung Jin Kang, Hong Hoe Koo, Jong Jin Seo, Ji Eun Choi, Daehee Kang

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14 Scopus citations

Abstract

To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma (Ptrend<0.05) in six genes (IL1RN, IL2, IL12RB1, JAK3, TNFRSF13B, and XRCC3). The most significant association was seen for IL2 variant rs2069762 (ORTG+GG vs. TT=3.43 (1.29-9.11), Ptrend=0.002, minP=0.005). These findings suggestthat common genetic variants in IL2 might play a role in the pathogenesis of childhood lymphoma.

Original languageEnglish
Pages (from-to)621-623
Number of pages3
JournalAsian Pacific Journal of Cancer Prevention
Volume13
Issue number2
DOIs
StatePublished - 2012

Keywords

  • Childhood lymphoma
  • Genetic variation
  • IL2
  • Korea

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