Genetic risk score raises the risk of incidence of chronic kidney disease in Korean general population-based cohort

Sohyun Yun, Miyeun Han, Hyo Jin Kim, Hyunsuk Kim, Eunjeong Kang, Sangsoo Kim, Curie Ahn, Kook-Hwan Oh

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Chronic kidney disease (CKD) is a common disease, affecting about 10% of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on the development of CKD. Methods: We conducted a genome-wide association (GWA) study regarding the development of CKD based on two population-based cohorts of Korean Genome Epidemiology Study. 3617 Koreans from two different cohorts, aged 40–49 years without CKD at initial visit, were included in our analysis. We used 2510 individuals in Ansan as the discovery set and another 1107 individuals from Ansung as the replication set. At baseline, members of both cohorts provided information on creatinine, and DNA samples were collected for genotyping. Single nucleotide polymorphisms that surpassed a significance threshold of P < 5 × 10−3 were selected. Results: A total of 281 among 3617 developed CKD during the follow-up period. Incident CKD group was older (P < 0.001), included more female (P < 0.001), and had more hypertension and diabetes (P < 0.001). We identified 12 SNPs that are associated with incident CKD in the GWA study and made genetic risk score using these SNPs. In multiple Cox regression analysis, genetic risk score was still a significant associated factor (HR 1.311, CI 1.201, 1.431, P < 0.001). Conclusions: We identified several loci highly associated with incident CKD. The findings suggest the need for further investigations on the genetic propensity for incident CKD.

Original languageEnglish
Pages (from-to)995-1003
Number of pages9
JournalClinical and Experimental Nephrology
Volume23
Issue number8
DOIs
StatePublished - 1 Aug 2019

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Chronic Renal Insufficiency
Incidence
Population
Single Nucleotide Polymorphism
Genome-Wide Association Study
Genetic Loci
Creatinine
Epidemiology
Regression Analysis
Genome
Hypertension
DNA

Keywords

  • Chronic kidney disease
  • Genetic risk score
  • Genome-wide association study

Cite this

Yun, Sohyun ; Han, Miyeun ; Kim, Hyo Jin ; Kim, Hyunsuk ; Kang, Eunjeong ; Kim, Sangsoo ; Ahn, Curie ; Oh, Kook-Hwan. / Genetic risk score raises the risk of incidence of chronic kidney disease in Korean general population-based cohort. In: Clinical and Experimental Nephrology. 2019 ; Vol. 23, No. 8. pp. 995-1003.
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abstract = "Background: Chronic kidney disease (CKD) is a common disease, affecting about 10{\%} of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on the development of CKD. Methods: We conducted a genome-wide association (GWA) study regarding the development of CKD based on two population-based cohorts of Korean Genome Epidemiology Study. 3617 Koreans from two different cohorts, aged 40–49 years without CKD at initial visit, were included in our analysis. We used 2510 individuals in Ansan as the discovery set and another 1107 individuals from Ansung as the replication set. At baseline, members of both cohorts provided information on creatinine, and DNA samples were collected for genotyping. Single nucleotide polymorphisms that surpassed a significance threshold of P < 5 × 10−3 were selected. Results: A total of 281 among 3617 developed CKD during the follow-up period. Incident CKD group was older (P < 0.001), included more female (P < 0.001), and had more hypertension and diabetes (P < 0.001). We identified 12 SNPs that are associated with incident CKD in the GWA study and made genetic risk score using these SNPs. In multiple Cox regression analysis, genetic risk score was still a significant associated factor (HR 1.311, CI 1.201, 1.431, P < 0.001). Conclusions: We identified several loci highly associated with incident CKD. The findings suggest the need for further investigations on the genetic propensity for incident CKD.",
keywords = "Chronic kidney disease, Genetic risk score, Genome-wide association study",
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Genetic risk score raises the risk of incidence of chronic kidney disease in Korean general population-based cohort. / Yun, Sohyun; Han, Miyeun; Kim, Hyo Jin; Kim, Hyunsuk; Kang, Eunjeong; Kim, Sangsoo; Ahn, Curie; Oh, Kook-Hwan.

In: Clinical and Experimental Nephrology, Vol. 23, No. 8, 01.08.2019, p. 995-1003.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Genetic risk score raises the risk of incidence of chronic kidney disease in Korean general population-based cohort

AU - Yun, Sohyun

AU - Han, Miyeun

AU - Kim, Hyo Jin

AU - Kim, Hyunsuk

AU - Kang, Eunjeong

AU - Kim, Sangsoo

AU - Ahn, Curie

AU - Oh, Kook-Hwan

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Background: Chronic kidney disease (CKD) is a common disease, affecting about 10% of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on the development of CKD. Methods: We conducted a genome-wide association (GWA) study regarding the development of CKD based on two population-based cohorts of Korean Genome Epidemiology Study. 3617 Koreans from two different cohorts, aged 40–49 years without CKD at initial visit, were included in our analysis. We used 2510 individuals in Ansan as the discovery set and another 1107 individuals from Ansung as the replication set. At baseline, members of both cohorts provided information on creatinine, and DNA samples were collected for genotyping. Single nucleotide polymorphisms that surpassed a significance threshold of P < 5 × 10−3 were selected. Results: A total of 281 among 3617 developed CKD during the follow-up period. Incident CKD group was older (P < 0.001), included more female (P < 0.001), and had more hypertension and diabetes (P < 0.001). We identified 12 SNPs that are associated with incident CKD in the GWA study and made genetic risk score using these SNPs. In multiple Cox regression analysis, genetic risk score was still a significant associated factor (HR 1.311, CI 1.201, 1.431, P < 0.001). Conclusions: We identified several loci highly associated with incident CKD. The findings suggest the need for further investigations on the genetic propensity for incident CKD.

AB - Background: Chronic kidney disease (CKD) is a common disease, affecting about 10% of the general population. The genetic component about CKD incidence in Asian population is not well known. The aim of the study is to find the genetic loci associated with incident CKD and to figure out the effect of genetic variation on the development of CKD. Methods: We conducted a genome-wide association (GWA) study regarding the development of CKD based on two population-based cohorts of Korean Genome Epidemiology Study. 3617 Koreans from two different cohorts, aged 40–49 years without CKD at initial visit, were included in our analysis. We used 2510 individuals in Ansan as the discovery set and another 1107 individuals from Ansung as the replication set. At baseline, members of both cohorts provided information on creatinine, and DNA samples were collected for genotyping. Single nucleotide polymorphisms that surpassed a significance threshold of P < 5 × 10−3 were selected. Results: A total of 281 among 3617 developed CKD during the follow-up period. Incident CKD group was older (P < 0.001), included more female (P < 0.001), and had more hypertension and diabetes (P < 0.001). We identified 12 SNPs that are associated with incident CKD in the GWA study and made genetic risk score using these SNPs. In multiple Cox regression analysis, genetic risk score was still a significant associated factor (HR 1.311, CI 1.201, 1.431, P < 0.001). Conclusions: We identified several loci highly associated with incident CKD. The findings suggest the need for further investigations on the genetic propensity for incident CKD.

KW - Chronic kidney disease

KW - Genetic risk score

KW - Genome-wide association study

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U2 - 10.1007/s10157-019-01731-8

DO - 10.1007/s10157-019-01731-8

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VL - 23

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JF - Clinical and Experimental Nephrology

SN - 1342-1751

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