Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics

Kyu Young Lee, Yongmin Ahn, Se Hyun Kim, Hee Gyoo Kang, Eun Jeong Joo

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Background: A circadian rhythm disturbance is one of the essential components of the phenotype of bipolar disorder. It has been reported that casein kinase 1 epsilon (CSNK1E), a member of the clock gene family, is associated with psychiatric phenotypes. Objectives: We performed a genetic association study to determine the genetic role of CSNK1E in bipolar disorder and circadian rhythm disturbances in the Korean population. Methods: The present study included 215 patients with bipolar disorder and 773 controls. Circadian characteristics were measured by the Korean version of the Composite Scale of Morningness (CS). Single-nucleotide polymorphisms (SNPs) of CSNK1E, rs1534891 and rs2075984, were genotyped. Chi-square analyses were performed to evaluate associations involving alleles and genotypes. Haplotype analysis was also performed, and the permutation p value was calculated. We also tested further associations involving these SNPs and scores on the CS. Results: We found a positive association between SNP rs2075984 and bipolar disorder in both the allelic (p =.003) and genotypic (p =.006) distributions. No allelic or genotypic association between SNP rs1534891 and bipolar disorder was observed. A significant association of haplotype with bipolar disorder was found (p =.033). However, no association between the CS and the genotype of either SNP was found in the total sample. Conclusion:CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample. This association does not seem to relate to the phase preference measured by the CS. Further studies on CSNK1E with larger samples and more SNPs are necessary.

Original languageEnglish
Pages (from-to)599-604
Number of pages6
JournalNordic Journal of Psychiatry
Volume72
Issue number8
DOIs
StatePublished - 17 Nov 2018

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Casein Kinase Iepsilon
Genetic Association Studies
Bipolar Disorder
Single Nucleotide Polymorphism
Genes
Circadian Rhythm
Haplotypes
Genotype
Phenotype
Psychiatry
Alleles

Keywords

  • Bipolar disorder
  • CSNK1E
  • circadian
  • composite scale
  • gene

Cite this

@article{56e62bc65fdb4c4ca1f88d50ce5842f5,
title = "Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics",
abstract = "Background: A circadian rhythm disturbance is one of the essential components of the phenotype of bipolar disorder. It has been reported that casein kinase 1 epsilon (CSNK1E), a member of the clock gene family, is associated with psychiatric phenotypes. Objectives: We performed a genetic association study to determine the genetic role of CSNK1E in bipolar disorder and circadian rhythm disturbances in the Korean population. Methods: The present study included 215 patients with bipolar disorder and 773 controls. Circadian characteristics were measured by the Korean version of the Composite Scale of Morningness (CS). Single-nucleotide polymorphisms (SNPs) of CSNK1E, rs1534891 and rs2075984, were genotyped. Chi-square analyses were performed to evaluate associations involving alleles and genotypes. Haplotype analysis was also performed, and the permutation p value was calculated. We also tested further associations involving these SNPs and scores on the CS. Results: We found a positive association between SNP rs2075984 and bipolar disorder in both the allelic (p =.003) and genotypic (p =.006) distributions. No allelic or genotypic association between SNP rs1534891 and bipolar disorder was observed. A significant association of haplotype with bipolar disorder was found (p =.033). However, no association between the CS and the genotype of either SNP was found in the total sample. Conclusion:CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample. This association does not seem to relate to the phase preference measured by the CS. Further studies on CSNK1E with larger samples and more SNPs are necessary.",
keywords = "Bipolar disorder, CSNK1E, circadian, composite scale, gene",
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Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics. / Lee, Kyu Young; Ahn, Yongmin; Kim, Se Hyun; Kang, Hee Gyoo; Joo, Eun Jeong.

In: Nordic Journal of Psychiatry, Vol. 72, No. 8, 17.11.2018, p. 599-604.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Genetic association study of CSNK1E gene in bipolar disorder and circadian characteristics

AU - Lee, Kyu Young

AU - Ahn, Yongmin

AU - Kim, Se Hyun

AU - Kang, Hee Gyoo

AU - Joo, Eun Jeong

PY - 2018/11/17

Y1 - 2018/11/17

N2 - Background: A circadian rhythm disturbance is one of the essential components of the phenotype of bipolar disorder. It has been reported that casein kinase 1 epsilon (CSNK1E), a member of the clock gene family, is associated with psychiatric phenotypes. Objectives: We performed a genetic association study to determine the genetic role of CSNK1E in bipolar disorder and circadian rhythm disturbances in the Korean population. Methods: The present study included 215 patients with bipolar disorder and 773 controls. Circadian characteristics were measured by the Korean version of the Composite Scale of Morningness (CS). Single-nucleotide polymorphisms (SNPs) of CSNK1E, rs1534891 and rs2075984, were genotyped. Chi-square analyses were performed to evaluate associations involving alleles and genotypes. Haplotype analysis was also performed, and the permutation p value was calculated. We also tested further associations involving these SNPs and scores on the CS. Results: We found a positive association between SNP rs2075984 and bipolar disorder in both the allelic (p =.003) and genotypic (p =.006) distributions. No allelic or genotypic association between SNP rs1534891 and bipolar disorder was observed. A significant association of haplotype with bipolar disorder was found (p =.033). However, no association between the CS and the genotype of either SNP was found in the total sample. Conclusion:CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample. This association does not seem to relate to the phase preference measured by the CS. Further studies on CSNK1E with larger samples and more SNPs are necessary.

AB - Background: A circadian rhythm disturbance is one of the essential components of the phenotype of bipolar disorder. It has been reported that casein kinase 1 epsilon (CSNK1E), a member of the clock gene family, is associated with psychiatric phenotypes. Objectives: We performed a genetic association study to determine the genetic role of CSNK1E in bipolar disorder and circadian rhythm disturbances in the Korean population. Methods: The present study included 215 patients with bipolar disorder and 773 controls. Circadian characteristics were measured by the Korean version of the Composite Scale of Morningness (CS). Single-nucleotide polymorphisms (SNPs) of CSNK1E, rs1534891 and rs2075984, were genotyped. Chi-square analyses were performed to evaluate associations involving alleles and genotypes. Haplotype analysis was also performed, and the permutation p value was calculated. We also tested further associations involving these SNPs and scores on the CS. Results: We found a positive association between SNP rs2075984 and bipolar disorder in both the allelic (p =.003) and genotypic (p =.006) distributions. No allelic or genotypic association between SNP rs1534891 and bipolar disorder was observed. A significant association of haplotype with bipolar disorder was found (p =.033). However, no association between the CS and the genotype of either SNP was found in the total sample. Conclusion:CSNK1E SNP rs2075984 seemed to play a significant role in the development of bipolar disorder in this Korean sample. This association does not seem to relate to the phase preference measured by the CS. Further studies on CSNK1E with larger samples and more SNPs are necessary.

KW - Bipolar disorder

KW - CSNK1E

KW - circadian

KW - composite scale

KW - gene

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U2 - 10.1080/08039488.2018.1509125

DO - 10.1080/08039488.2018.1509125

M3 - Article

VL - 72

SP - 599

EP - 604

JO - Nordic Journal of Psychiatry

JF - Nordic Journal of Psychiatry

SN - 0803-9488

IS - 8

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