Genetic Analysis of Ancient Clonorchis sinensis Eggs Attained from Goryeong Mummy of Joseon Dynasty Period

Chang Seok Oh, Min Seo, Hye Jin Lee, Myeung Ju Kim, Do Seon Lim, Dong Hoon Shin

Research output: Contribution to journalArticlepeer-review

Abstract

Although Clonorchis sinensis is a parasite that still infects many people in East Asia, its genetics remain largely unknown. We conducted ancient DNA analysis of C. sinensis eggs obtained from a Joseon period mummy newly discovered in South Korea. Clonorchis sinensis DNA was amplified for internal transcribed spacer 1, cytochrome c oxidase subunit 1, and NADH dehydrogenase subunit 2 and 5 genes. The results of BLAST/NCBI showed that the consensus sequences were 98.24 to 100% identical to the modern and ancient C. sinensis sequences reported from Korea, China, Japan, and other Asian countries. Our report helps to fill in the genetic profile of ancient C. sinensis strains that infected East Asian people hundreds of years ago.

Original languageEnglish
Pages (from-to)70-78
Number of pages9
JournalJournal of Parasitology
Volume108
Issue number1
DOIs
StatePublished - 1 Feb 2022

Keywords

  • Ancient DNA
  • Clonorchis sinensis
  • Goryeong
  • Joseon period
  • Korea
  • Mummy

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