Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV

Fanny W.F. Shum, Shanelle W. Ko, Yong Seok Lee, Bong Kiun Kaang, Min Zhuo

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25 Scopus citations


Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major ranscription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior. Here, CaMKIV knockout mice (CaMKIV-/-) were tested in a battery of stress and anxiety-related behavioral tests, to determine if CaMKIV plays a role in emotional behavior. CaMKIW-/-exhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice. Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. In addition, CaMKIV-/- mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior.

Original languageEnglish
Article number22
JournalMolecular Pain
StatePublished - 15 Aug 2005


  • Anxiety
  • CaMKIV
  • Knockout mice
  • Microarray
  • Stress-induced analgesia

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