Gemcitabine and oxaliplatin combination as first-line treatment for advanced pancreatic cancer: A multicenter phase II study

Kyung Hee Lee, Min Kyoung Kim, Yeol Hong Kim, Baek Yeol Ryoo, Ho Yeong Lim, Hong Suk Song, Hoon Kyo Kim, Myung Ah Lee, Seock Ah Im, Heung Moon Chang, Jae Yong Cho, Dae Young Zang, Bong Seog Kim, Jun Suk Kim

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12 Scopus citations

Abstract

Purpose: Gemcitabine is the only drug approved for single-agent therapy in advanced pancreatic carcinoma (APC). Gemcitabine-based combination chemotherapy has not yet shown promising results. Methods: This multicenter phase II study enrolled previously untreated patients with locally advanced and/or metastatic pancreatic adenocarcinoma. Patients received 1,000 mg/m2 gemcitabine, 100-min infusion, day 1 and 100 mg/m2 oxaliplatin, 2-h infusion, day 2; q2w. The primary end point was response rate (RR). Results: Thirteen study centers enrolled 48 eligible patients of which 44 were evaluable. The RR, median overall survival, and median time to progression were 18.2%, 9.4 and 5.6 months, respectively. Sixteen patients (36.4%) experienced clinical benefit. The global quality of life scores improved by 11.71. Grade 3/4 peripheral sensory neuropathy was noted (2.1%), while the most common hematologic toxicity was anemia (grade 3/4, 6.3%). Conclusions: Gemcitabine and oxaliplatin combination chemotherapy showed a promising activity in APC patients and was well tolerated.

Original languageEnglish
Pages (from-to)317-325
Number of pages9
JournalCancer Chemotherapy and Pharmacology
Volume64
Issue number2
DOIs
StatePublished - 1 Jul 2009

Keywords

  • Advanced pancreatic cancer
  • Combination chemotherapy
  • GEMOX
  • Gemcitabine
  • Oxaliplatin

Cite this

Lee, K. H., Kim, M. K., Kim, Y. H., Ryoo, B. Y., Lim, H. Y., Song, H. S., Kim, H. K., Lee, M. A., Im, S. A., Chang, H. M., Cho, J. Y., Zang, D. Y., Kim, B. S., & Kim, J. S. (2009). Gemcitabine and oxaliplatin combination as first-line treatment for advanced pancreatic cancer: A multicenter phase II study. Cancer Chemotherapy and Pharmacology, 64(2), 317-325. https://doi.org/10.1007/s00280-008-0873-9