Functional connectivity of resting state EEG and symptom severity in patients with post-traumatic stress disorder

Seung Hwan Lee, Sunkyung Yoon, Jeong In Kim, Seung Hyun Jin, Chun Kee Chung

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objectives: Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD. Methods: Thirty-three PTSD patients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSD patients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands. Results: Dnodal and Enodal of the beta and gamma bands were decreased in PTSD patients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms. Conclusion: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.

Original languageEnglish
Pages (from-to)51-57
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume51
DOIs
StatePublished - 3 Jun 2014

Fingerprint

Post-Traumatic Stress Disorders
Electroencephalography
Arousal
Brain Diseases
Electrodes
Biomarkers
Communication
Depression

Keywords

  • Biomarker
  • EEG
  • Functional connectivity
  • PTSD
  • Resting state

Cite this

@article{0080e49300ad4f6aab20d6f73245455a,
title = "Functional connectivity of resting state EEG and symptom severity in patients with post-traumatic stress disorder",
abstract = "Objectives: Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD. Methods: Thirty-three PTSD patients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSD patients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands. Results: Dnodal and Enodal of the beta and gamma bands were decreased in PTSD patients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms. Conclusion: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.",
keywords = "Biomarker, EEG, Functional connectivity, PTSD, Resting state",
author = "Lee, {Seung Hwan} and Sunkyung Yoon and Kim, {Jeong In} and Jin, {Seung Hyun} and Chung, {Chun Kee}",
year = "2014",
month = "6",
day = "3",
doi = "10.1016/j.pnpbp.2014.01.008",
language = "English",
volume = "51",
pages = "51--57",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",

}

Functional connectivity of resting state EEG and symptom severity in patients with post-traumatic stress disorder. / Lee, Seung Hwan; Yoon, Sunkyung; Kim, Jeong In; Jin, Seung Hyun; Chung, Chun Kee.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 51, 03.06.2014, p. 51-57.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Functional connectivity of resting state EEG and symptom severity in patients with post-traumatic stress disorder

AU - Lee, Seung Hwan

AU - Yoon, Sunkyung

AU - Kim, Jeong In

AU - Jin, Seung Hyun

AU - Chung, Chun Kee

PY - 2014/6/3

Y1 - 2014/6/3

N2 - Objectives: Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD. Methods: Thirty-three PTSD patients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSD patients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands. Results: Dnodal and Enodal of the beta and gamma bands were decreased in PTSD patients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms. Conclusion: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.

AB - Objectives: Post-traumatic stress disorder (PTSD) is thought to be a brain network disorder. This study aimed to examine the resting-state functional connectivity (FC) in patients with PTSD. Methods: Thirty-three PTSD patients and 30 age- and gender-matched healthy controls were recruited. Symptom severity of the PTSD patients was assessed, and 62-channel EEG was measured. EEGs were recorded during the resting state, with the eyes closed. Three nodal network measures to assess nodal centrality [nodal degree (Dnodal; connection strength), nodal efficiency (Enodal; communication efficiency), and betweenness centrality (BC; connection centrality)] were calculated in the delta, theta, alpha, beta, and gamma bands. Results: Dnodal and Enodal of the beta and gamma bands were decreased in PTSD patients compared to healthy controls. These decreased nodal centrality values were observed primarily at the frontocentral electrodes. In addition, Dnodal of the beta and gamma bands was significantly correlated with depressive symptoms and increased arousal symptoms, respectively. Enodal of the beta and gamma bands was significantly correlated with re-experience, increased arousal, and the severity and frequency of general PTSD symptoms. Conclusion: Compared to controls, patients with PTSD were found to have decreased resting-state FC, and these FC measures were significantly correlated with PTSD symptom severity. Our results suggest that resting-state FC could be a useful biomarker for PTSD.

KW - Biomarker

KW - EEG

KW - Functional connectivity

KW - PTSD

KW - Resting state

UR - http://www.scopus.com/inward/record.url?scp=84893419074&partnerID=8YFLogxK

U2 - 10.1016/j.pnpbp.2014.01.008

DO - 10.1016/j.pnpbp.2014.01.008

M3 - Article

C2 - 24447944

AN - SCOPUS:84893419074

VL - 51

SP - 51

EP - 57

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

ER -