Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors

Jongha Lee, Hye Rim Cho, Gi Doo Cha, Hyunseon Seo, Seunghyun Lee, Chul Kee Park, Jin Wook Kim, Shutao Qiao, Liu Wang, Dayoung Kang, Taegyu Kang, Tomotsugu Ichikawa, Jonghoon Kim, Hakyong Lee, Woongchan Lee, Sanghoek Kim, Soon Tae Lee, Nanshu Lu, Taeghwan Hyeon, Seung Hong ChoiDae Hyeong Kim

Research output: Contribution to journalArticle

Abstract

Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application.

Original languageEnglish
Article number5205
JournalNature Communications
Volume10
Issue number1
DOIs
StatePublished - 1 Dec 2019

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Lee, J., Cho, H. R., Cha, G. D., Seo, H., Lee, S., Park, C. K., Kim, J. W., Qiao, S., Wang, L., Kang, D., Kang, T., Ichikawa, T., Kim, J., Lee, H., Lee, W., Kim, S., Lee, S. T., Lu, N., Hyeon, T., ... Kim, D. H. (2019). Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors. Nature Communications, 10(1), [5205]. https://doi.org/10.1038/s41467-019-13198-y