Fine needle aspiration cytology of palpable breast lesions

Inae Park, Eui Keun Ham

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Abstract

OBJECTIVE: To evaluate the use of fine needle aspirationcytology (FNAC) in the management of benign andmalignant breast disease in an outpatient breast clinicand to determine the guidelinesfor reporting on FNACof breast lesions, we evaluatedthe test results in correlationwith the histologic diagnosis.STUDY DESIGN: We evaluatethe test results of 669cases of FNAC of the breastin 17 months in our outpatient breast clinic in correlationwith the histologic diagnosis, histologic subtype accordingto the Japan Mammary Cancer Society classificationand mammography results in false negative cases.RESULTS: Among 669 cases, 25.3% were inadequatefor cytologic diagnosis. An analysis of the results usingthe two-by-four contingency table, including cases withinadequate cytologic diagnosis, showed that 10.6% and1.0% had false negative and false positive cytologic diagnoses, respectively; sensitivity and specificity were76.9% and 91.6%, respectively. The false negative rate of10.6% was higher than expected, and those belongedmostly to the “inadequate” cytologic diagnosis categoryeven though they were discrete, obviously malignantmasses clinically. To try to explain this, we compared thecytologic results and histologic subtype according to theJapan Mammary Cancer Society classification and themammography results. Of 73 cases of infiltrating ductalcarcinoma in which retrospective reexamination of thehistology slide was possible,27 (37.0%) were papillotubulartype, 11 (15.1%)were solid-tubular type and35 cases (47.9%) were scirrhoustype. Although thescirrhous subtype was only37.0% in the group in whicha cytologic diagnosis of carcinomawas possible, more than two-thirds of the cases offalse negative cytology were scirrhous type and had malignantmammographic findings. This finding was statisticallysignificant.CONCLUSION: In cases of ductal carcinoma of scirrhoussubtype, the FNAC tended to be inadequate andfalse negative, but mammography showed better discriminationin such cases.

Original languageEnglish
Pages (from-to)1131-1138
Number of pages8
JournalActa Cytologica
Volume41
Issue number4
DOIs
StatePublished - 1 Jan 1997

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Fine Needle Biopsy
Cell Biology
Breast
Needles
Mammography
Breast Neoplasms
Ductal Carcinoma
Breast Diseases
Ambulatory Care Facilities
Japan
Outpatients
Sensitivity and Specificity

Keywords

  • Aspiration cytology
  • Breast neoplasms
  • Histology

Cite this

Park, Inae ; Ham, Eui Keun. / Fine needle aspiration cytology of palpable breast lesions. In: Acta Cytologica. 1997 ; Vol. 41, No. 4. pp. 1131-1138.
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abstract = "OBJECTIVE: To evaluate the use of fine needle aspirationcytology (FNAC) in the management of benign andmalignant breast disease in an outpatient breast clinicand to determine the guidelinesfor reporting on FNACof breast lesions, we evaluatedthe test results in correlationwith the histologic diagnosis.STUDY DESIGN: We evaluatethe test results of 669cases of FNAC of the breastin 17 months in our outpatient breast clinic in correlationwith the histologic diagnosis, histologic subtype accordingto the Japan Mammary Cancer Society classificationand mammography results in false negative cases.RESULTS: Among 669 cases, 25.3{\%} were inadequatefor cytologic diagnosis. An analysis of the results usingthe two-by-four contingency table, including cases withinadequate cytologic diagnosis, showed that 10.6{\%} and1.0{\%} had false negative and false positive cytologic diagnoses, respectively; sensitivity and specificity were76.9{\%} and 91.6{\%}, respectively. The false negative rate of10.6{\%} was higher than expected, and those belongedmostly to the “inadequate” cytologic diagnosis categoryeven though they were discrete, obviously malignantmasses clinically. To try to explain this, we compared thecytologic results and histologic subtype according to theJapan Mammary Cancer Society classification and themammography results. Of 73 cases of infiltrating ductalcarcinoma in which retrospective reexamination of thehistology slide was possible,27 (37.0{\%}) were papillotubulartype, 11 (15.1{\%})were solid-tubular type and35 cases (47.9{\%}) were scirrhoustype. Although thescirrhous subtype was only37.0{\%} in the group in whicha cytologic diagnosis of carcinomawas possible, more than two-thirds of the cases offalse negative cytology were scirrhous type and had malignantmammographic findings. This finding was statisticallysignificant.CONCLUSION: In cases of ductal carcinoma of scirrhoussubtype, the FNAC tended to be inadequate andfalse negative, but mammography showed better discriminationin such cases.",
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Fine needle aspiration cytology of palpable breast lesions. / Park, Inae; Ham, Eui Keun.

In: Acta Cytologica, Vol. 41, No. 4, 01.01.1997, p. 1131-1138.

Research output: Contribution to journalArticleResearchpeer-review

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