Family- and population-based association studies of monoamine oxidase A and autism spectrum disorders in Korean

Hee Jeong Yoo, Seong Kyu Lee, Mira Park, In Hee Cho, Seung Hee Hyun, Je Chul Lee, So Young Yang, Soon Ae Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Monoamine oxidase A gene (MAOA) has been thought to be a candidate gene implicated in autism spectrum disorder (ASD). This study evaluates the relationship between ASDs and MAOA markers (i.e., uVNTR and four single nucleotide polymorphisms (SNPs)) in 151 Korean family trios with children diagnosed with ASDs, and 193 unrelated Korean controls. The result of case-control global haplotype analysis also showed a statistically significant difference in haplotype frequencies between ASD patients and controls (male d.f. = 5, p < 0.001; female d.f. = 7, p < 0.001). With the specific haplotype analyses, the frequencies of the most frequent haplotype (AGG) with three SNPs (rs5906883 + rs1137070 + rs3027407) in ASD showed significant statistical differences between ASD patients and controls in both the male and female groups (d.f. = 1, male p = 0.001, female p < 0.001). In a family-based association test (FBAT) analysis, it was observed that, in the dominant model, a three-repeat allele of a MAOA-uVNTR marker was preferentially transmitted in ASDs (Z = 2.213, p = 0.027). Moreover, in the global haplotype analysis, the statistically significant evidence of associations with ASD were demonstrated in additive and dominant models (additive χ2 = 11.349, d.f. = 2, p = 0.003; dominant χ2 = 6.198, d.f. = 2, p = 0.045).

Original languageEnglish
Pages (from-to)172-176
Number of pages5
JournalNeuroscience Research
Volume63
Issue number3
DOIs
StatePublished - 1 Mar 2009

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Monoamine Oxidase
Haplotypes
Population
Genes
Single Nucleotide Polymorphism
Alleles
Autism Spectrum Disorder

Keywords

  • Association
  • Autism spectrum disorders (ASD)
  • Monoamine oxidase A (MAOA)
  • Polymorphism
  • Transmission disequilibrium test (TDT)

Cite this

Yoo, Hee Jeong ; Lee, Seong Kyu ; Park, Mira ; Cho, In Hee ; Hyun, Seung Hee ; Lee, Je Chul ; Yang, So Young ; Kim, Soon Ae. / Family- and population-based association studies of monoamine oxidase A and autism spectrum disorders in Korean. In: Neuroscience Research. 2009 ; Vol. 63, No. 3. pp. 172-176.
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Family- and population-based association studies of monoamine oxidase A and autism spectrum disorders in Korean. / Yoo, Hee Jeong; Lee, Seong Kyu; Park, Mira; Cho, In Hee; Hyun, Seung Hee; Lee, Je Chul; Yang, So Young; Kim, Soon Ae.

In: Neuroscience Research, Vol. 63, No. 3, 01.03.2009, p. 172-176.

Research output: Contribution to journalArticle

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