Korean Sources

Translated title of the contribution: Expression of P-glycoprotein and apoptosis in diffuse large B-cell lymphoma

Ji Eun Kim, Young A Kim, Mee Soo Chang, Yunkyeong Jeon, Jin Ho Paik, Seon Og Yoon

Research output: Contribution to journalArticle

Abstract

Background : Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma which responds well to conventional chemotherapy. However, quite a few patients have a recurrence with more aggressive forms after completion of therapy. Multidrug resistance proteins (MRP) are related to this process in several ways such as cell cycle alteration and modulation of apoptosis. Methods : We investigated the expression of P-glycoprotein (Gp), one of the well-known MRP, as well as apoptosis associated proteins in DLBCL. Immunohistochemical staining for Gp, p53, Bcl-2, Ki-67, active caspase 3 and FADD was done in forty DLBCL cases. The association between MRP and apoptosis associated proteins to clinical findings was also tested. Results : Twenty-nine patients out of 40 (73%) with DLBCL were positive for Gp, and 26 cases (65%) had a strong positive for Gp. Gp expression was stronger in high-grade lesions than in low-grade lesions and was associated to Bcl-2 expression. However, we could not find an adverse impact of Gp expression on patients' overall survival or relapse free survival rate. Conclusions : Our study revealed a high frequency of expression for Gp in DLBCL with a possible relationship between the expressions of Gp to apoptosis associated proteins.

Original languageKorean
Pages (from-to)317-320
Number of pages4
JournalKorean Journal of Pathology
Volume43
Issue number4
DOIs
StatePublished - 1 Aug 2009

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Lymphoma, Large B-Cell, Diffuse
P-Glycoprotein
Apoptosis
P-Glycoproteins
Multidrug Resistance-Associated Proteins
Recurrence
Proteins
Caspase 3
Lymphoma
Cell Cycle
Survival Rate
Staining and Labeling
Drug Therapy
Survival

Cite this

Kim, Ji Eun ; Kim, Young A ; Chang, Mee Soo ; Jeon, Yunkyeong ; Paik, Jin Ho ; Yoon, Seon Og. / Korean Sources. In: Korean Journal of Pathology. 2009 ; Vol. 43, No. 4. pp. 317-320.
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abstract = "Background : Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma which responds well to conventional chemotherapy. However, quite a few patients have a recurrence with more aggressive forms after completion of therapy. Multidrug resistance proteins (MRP) are related to this process in several ways such as cell cycle alteration and modulation of apoptosis. Methods : We investigated the expression of P-glycoprotein (Gp), one of the well-known MRP, as well as apoptosis associated proteins in DLBCL. Immunohistochemical staining for Gp, p53, Bcl-2, Ki-67, active caspase 3 and FADD was done in forty DLBCL cases. The association between MRP and apoptosis associated proteins to clinical findings was also tested. Results : Twenty-nine patients out of 40 (73{\%}) with DLBCL were positive for Gp, and 26 cases (65{\%}) had a strong positive for Gp. Gp expression was stronger in high-grade lesions than in low-grade lesions and was associated to Bcl-2 expression. However, we could not find an adverse impact of Gp expression on patients' overall survival or relapse free survival rate. Conclusions : Our study revealed a high frequency of expression for Gp in DLBCL with a possible relationship between the expressions of Gp to apoptosis associated proteins.",
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Korean Sources. / Kim, Ji Eun; Kim, Young A; Chang, Mee Soo; Jeon, Yunkyeong; Paik, Jin Ho; Yoon, Seon Og.

In: Korean Journal of Pathology, Vol. 43, No. 4, 01.08.2009, p. 317-320.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Korean Sources

AU - Kim, Ji Eun

AU - Kim, Young A

AU - Chang, Mee Soo

AU - Jeon, Yunkyeong

AU - Paik, Jin Ho

AU - Yoon, Seon Og

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background : Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma which responds well to conventional chemotherapy. However, quite a few patients have a recurrence with more aggressive forms after completion of therapy. Multidrug resistance proteins (MRP) are related to this process in several ways such as cell cycle alteration and modulation of apoptosis. Methods : We investigated the expression of P-glycoprotein (Gp), one of the well-known MRP, as well as apoptosis associated proteins in DLBCL. Immunohistochemical staining for Gp, p53, Bcl-2, Ki-67, active caspase 3 and FADD was done in forty DLBCL cases. The association between MRP and apoptosis associated proteins to clinical findings was also tested. Results : Twenty-nine patients out of 40 (73%) with DLBCL were positive for Gp, and 26 cases (65%) had a strong positive for Gp. Gp expression was stronger in high-grade lesions than in low-grade lesions and was associated to Bcl-2 expression. However, we could not find an adverse impact of Gp expression on patients' overall survival or relapse free survival rate. Conclusions : Our study revealed a high frequency of expression for Gp in DLBCL with a possible relationship between the expressions of Gp to apoptosis associated proteins.

AB - Background : Diffuse large B-cell lymphoma (DLBCL) is the most common type of malignant lymphoma which responds well to conventional chemotherapy. However, quite a few patients have a recurrence with more aggressive forms after completion of therapy. Multidrug resistance proteins (MRP) are related to this process in several ways such as cell cycle alteration and modulation of apoptosis. Methods : We investigated the expression of P-glycoprotein (Gp), one of the well-known MRP, as well as apoptosis associated proteins in DLBCL. Immunohistochemical staining for Gp, p53, Bcl-2, Ki-67, active caspase 3 and FADD was done in forty DLBCL cases. The association between MRP and apoptosis associated proteins to clinical findings was also tested. Results : Twenty-nine patients out of 40 (73%) with DLBCL were positive for Gp, and 26 cases (65%) had a strong positive for Gp. Gp expression was stronger in high-grade lesions than in low-grade lesions and was associated to Bcl-2 expression. However, we could not find an adverse impact of Gp expression on patients' overall survival or relapse free survival rate. Conclusions : Our study revealed a high frequency of expression for Gp in DLBCL with a possible relationship between the expressions of Gp to apoptosis associated proteins.

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KW - Diffuse

KW - Large B-cell

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KW - P-glycoprotein

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