@inproceedings{19b2ca9be9ba4913abaecc0d09db58b6,
title = "Expression of MMP-2, MMP-9, and urokinase-type plasminogen activator in cervical intraepithelial neoplasia",
abstract = "Matrix metalloproteinase-2 (MMP-2), MMP-9, and urokinase-type plasminogen activator (uPA) are important factors for cancer invasion and metastasis, degrading the extracellular matrix. They are also associated with angiogenesis. Angiogenic phenotype is another feature of high-grade cervical intraepithelial neoplasia (CIN). However, their associations with the progression of low-grade CIN to high-grade CIN are unexplored. We investigated whether these proteolytic enzyme expressions correlate with the progression of CIN. A total of 39 paraffin-embedded specimens from 10 patients with CIN grade 1, nine with CIN grade 2, and 20 with CIN grade 3 were assessed immunohistochemically by specific antibodies against MMP-2, MMP-9, and uPA. MMP-9 expression was higher in CIN 3 lesions (47.4%) than in CIN 1 (22.2%) and CIN 2 (20.2%) lesions, although the difference failed to reach statistical significance. The expression level of uPA and MMP-2 was not associated with the grade of CIN lesions. Interestingly, we found a significant association between expressions of uPA and MMP-2 (P = 0.028). Our results suggest that MMP-9 might play a role in the progression of CIN.",
keywords = "Cervical intraepithelial neoplasia, Matrix metalloproteinase, Urokinase-type plasminogen activator",
author = "No, {Jae Hong} and Hoenil Jo and Kim, {Su Hyeong} and Park, {In Ae} and Daehee Kang and Lee, {Chae Hyeong} and Han, {Seung Su} and Kim, {Jae Weon} and Park, {Noh Hyun} and Kang, {Soon Beom} and Song, {Yong Sang}",
year = "2009",
month = aug,
doi = "10.1111/j.1749-6632.2009.04898.x",
language = "English",
isbn = "9781573317375",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "100--104",
booktitle = "Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways",
}