Exposure to gene-environment interactions before 1 year of age may favor the development of atopic dermatitis

Jung Yong Lee, Ju Hee Seo, Ji Won Kwon, Jinho Yu, Byoung Ju Kim, So Yeon Lee, Hyo Bin Kim, Woo Kyung Kim, Kyung Won Kim, Yee Jin Shin, Soo Jong Hong

Research output: Contribution to journalReview article

30 Citations (Scopus)

Abstract

Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalInternational Archives of Allergy and Immunology
Volume157
Issue number4
DOIs
StatePublished - 1 Mar 2012

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Gene-Environment Interaction
Atopic Dermatitis
Eczema
Environmental Exposure
Korea
Hypersensitivity
Asthma
Odds Ratio

Keywords

  • Atopic dermatitis
  • Gene-environment interaction
  • Prevalence
  • Risk factor

Cite this

Lee, Jung Yong ; Seo, Ju Hee ; Kwon, Ji Won ; Yu, Jinho ; Kim, Byoung Ju ; Lee, So Yeon ; Kim, Hyo Bin ; Kim, Woo Kyung ; Kim, Kyung Won ; Shin, Yee Jin ; Hong, Soo Jong. / Exposure to gene-environment interactions before 1 year of age may favor the development of atopic dermatitis. In: International Archives of Allergy and Immunology. 2012 ; Vol. 157, No. 4. pp. 363-371.
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abstract = "Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3{\%}, the 12-month prevalence of itchy flexural eczema was 18.0{\%}, the lifetime prevalence of AD diagnosis was 31.3{\%}, and the 12-month prevalence of AD treatment was 14.5{\%}. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3{\%}, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.",
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Exposure to gene-environment interactions before 1 year of age may favor the development of atopic dermatitis. / Lee, Jung Yong; Seo, Ju Hee; Kwon, Ji Won; Yu, Jinho; Kim, Byoung Ju; Lee, So Yeon; Kim, Hyo Bin; Kim, Woo Kyung; Kim, Kyung Won; Shin, Yee Jin; Hong, Soo Jong.

In: International Archives of Allergy and Immunology, Vol. 157, No. 4, 01.03.2012, p. 363-371.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Exposure to gene-environment interactions before 1 year of age may favor the development of atopic dermatitis

AU - Lee, Jung Yong

AU - Seo, Ju Hee

AU - Kwon, Ji Won

AU - Yu, Jinho

AU - Kim, Byoung Ju

AU - Lee, So Yeon

AU - Kim, Hyo Bin

AU - Kim, Woo Kyung

AU - Kim, Kyung Won

AU - Shin, Yee Jin

AU - Hong, Soo Jong

PY - 2012/3/1

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N2 - Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.

AB - Background: The aims of this study were to determine (1) the prevalence of atopic dermatitis (AD) in Seoul, Korea, and (2) the influence of environmental and genetic factors on disease risk. Methods: A questionnaire survey was conducted in 5,036 primary school children and 4,607 middle school children in 2008. For each child, a modified version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire and a questionnaire assessing exposure to environmental variables were completed. Results: In primary school children, the lifetime prevalence of itchy eczema was 24.3%, the 12-month prevalence of itchy flexural eczema was 18.0%, the lifetime prevalence of AD diagnosis was 31.3%, and the 12-month prevalence of AD treatment was 14.5%. In middle school children, the corresponding rates were 16.0, 10.8, 22.1, and 8.3%, respectively. These rates are significantly higher than those reported in similar studies conducted in 1995 and 2000. In both primary and middle school children, a parental history of allergic disease and a history of having moved into a newly built house before 1 year of age were independently associated with a risk for current AD. For current AD, the prevalence odds ratio was higher in the subgroup with both a genetic and a specific environmental risk factor than in the subgroup with no risk factor or subgroups with only one risk factor. Conclusions: The prevalence of AD in primary and middle school children in Seoul has increased. Its development may be influenced by gene-environment interactions, particularly before 1 year of age.

KW - Atopic dermatitis

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KW - Prevalence

KW - Risk factor

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DO - 10.1159/000328778

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C2 - 22123373

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VL - 157

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JO - International Archives of Allergy and Immunology

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