Exploring the potential of ex-vivo 7-T magnetic resonance imaging on patients with clinically significant prostate cancer: visibility and size perspective

Hyungwoo Ahn, Jung Kwon Kim, Sung Il Hwang, Sung Kyu Hong, Seok Soo Byun, Sang Hun Song, Gheeyoung Choe, Hye Mi Jee, Sung Woo Park

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Despite progress in multiparametric magnetic resonance imaging (MRI), issues of prostate cancer invisibility and underestimated tumor burden persist. This study investigates the potential of an ultra-high field MRI at 7-T in an ex-vivo setting to address these limitations. Methods: This prospective study included 54 tumors from 20 treatment-naïve clinically significant prostate cancer patients, confirmed by biopsy, despite negative findings on preoperative 3-T MRI. Ex-vivo 7-T MRI of resected prostates was performed, with assessment on tumor visibility and size. Factors influencing visibility were analyzed using logistic regression analyses. Results: Tumor visibility was confirmed in 80% of patients, and 48% of all tumors on ex-vivo imaging. Gleason pattern 4 percentage (odds ratio 1.09) and tumor size on pathology (odds ratio 1.36) were significantly associated with visibility (P < 0.05). Mean MRI-visible and invisible tumor sizes were 10.5 mm and 5.3 mm, respectively. The size discrepancy between MRI and pathology was 2.7 mm. Conclusion: Tumor visibility on ex-vivo 7-T MRI was influenced by tumor grade and size. The notable tumor visibility initially overlooked on 3-T MRI, along with small size discrepancy with pathology, suggests potential improvements in resolution.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalProstate International
Volume12
Issue number2
DOIs
StatePublished - Jun 2024

Bibliographical note

Publisher Copyright:
© 2024 The Asian Pacific Prostate Society

Keywords

  • Biopsy
  • Magnetic resonance imaging
  • Prastatectomy
  • Prostatic neoplasms

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