Evaluation of various hepatic lesions with positron emission tomography

Hyun Bae Son, Chul Ju Han, Beung Il Kim, Jin Kim, Sook Hyang Jeong, You Cheoul Kim, Jhin Oh Lee, Chang Yun Choi, Sang Mu Im

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

BACKGROUND/AIMS: [18F]FDG-PET is a functional imaging modality reflecting cellular glucose metabolism. In most malignant cells, accumulation and trapping of [18F]FDG allows the visualization of increased uptake compared with normal cells. The aim of this study was to assess the value of PET in differentiating benign from malignant hepatic lesions and to determine in which types of hepatic tumors PET can help evaluate stage, monitor response to therapy, and detect recurrence. METHODS: Eighty patients with liver lesions were enrolled (hepatocellular carcinoma 34, cholangiocarcinoma 8, metastatic liver cancer 25, hemangioma 6, liver abscess 7). Liver metastases were 22 adenocarcinoma, 2 lymphoma, 2 squamous cell carcinoma. The PET images of these patients were analyzed. SUV and lesion-to-normal liver background SUV ratio were obtained and compared among the disease groups. RESULTS: All liver metastases and all cholangiocarcinomas had increased uptake value, with SUV ratios greater than 2. Hepatocellular carcinoma had SUV ratios greater than 2 in 20 of 34 patients (59%). All hemangiomas had poor uptake, a SUV ratio of less than 2. All liver abscesses showed definite uptake. CONCLUSIONS: The PET technique using FDG static imaging was useful in differentiating malignant from benign lesions of the liver in limited situations. Limitations included false negative results in some patients with hepatocellular carcinoma. Liver abscesses raised problems in differential diagnosis from malignant liver tumors. The findings of this study suggest that the PET technique might be applied in tumor staging and the detection of recurrence, as well as monitoring responses to therapy for all adenocarcinomas and some hepatocellular carcinomas.

Original languageEnglish
Pages (from-to)472-480
Number of pages9
JournalTaehan Kan Hakhoe chi = The Korean journal of hepatology
Volume8
Issue number4
StatePublished - 1 Jan 2002

Fingerprint

Positron-Emission Tomography
Liver
Liver Abscess
Hepatocellular Carcinoma
Cholangiocarcinoma
Fluorodeoxyglucose F18
Hemangioma
Adenocarcinoma
Neoplasm Metastasis
Recurrence
Neoplasm Staging
Liver Neoplasms
Squamous Cell Carcinoma
Lymphoma
Neoplasms
Differential Diagnosis
Glucose
Therapeutics

Cite this

Son, H. B., Han, C. J., Kim, B. I., Kim, J., Jeong, S. H., Kim, Y. C., ... Im, S. M. (2002). Evaluation of various hepatic lesions with positron emission tomography. Taehan Kan Hakhoe chi = The Korean journal of hepatology, 8(4), 472-480.
Son, Hyun Bae ; Han, Chul Ju ; Kim, Beung Il ; Kim, Jin ; Jeong, Sook Hyang ; Kim, You Cheoul ; Lee, Jhin Oh ; Choi, Chang Yun ; Im, Sang Mu. / Evaluation of various hepatic lesions with positron emission tomography. In: Taehan Kan Hakhoe chi = The Korean journal of hepatology. 2002 ; Vol. 8, No. 4. pp. 472-480.
@article{36a4401295cb4da9a8db557d28e3f16b,
title = "Evaluation of various hepatic lesions with positron emission tomography",
abstract = "BACKGROUND/AIMS: [18F]FDG-PET is a functional imaging modality reflecting cellular glucose metabolism. In most malignant cells, accumulation and trapping of [18F]FDG allows the visualization of increased uptake compared with normal cells. The aim of this study was to assess the value of PET in differentiating benign from malignant hepatic lesions and to determine in which types of hepatic tumors PET can help evaluate stage, monitor response to therapy, and detect recurrence. METHODS: Eighty patients with liver lesions were enrolled (hepatocellular carcinoma 34, cholangiocarcinoma 8, metastatic liver cancer 25, hemangioma 6, liver abscess 7). Liver metastases were 22 adenocarcinoma, 2 lymphoma, 2 squamous cell carcinoma. The PET images of these patients were analyzed. SUV and lesion-to-normal liver background SUV ratio were obtained and compared among the disease groups. RESULTS: All liver metastases and all cholangiocarcinomas had increased uptake value, with SUV ratios greater than 2. Hepatocellular carcinoma had SUV ratios greater than 2 in 20 of 34 patients (59{\%}). All hemangiomas had poor uptake, a SUV ratio of less than 2. All liver abscesses showed definite uptake. CONCLUSIONS: The PET technique using FDG static imaging was useful in differentiating malignant from benign lesions of the liver in limited situations. Limitations included false negative results in some patients with hepatocellular carcinoma. Liver abscesses raised problems in differential diagnosis from malignant liver tumors. The findings of this study suggest that the PET technique might be applied in tumor staging and the detection of recurrence, as well as monitoring responses to therapy for all adenocarcinomas and some hepatocellular carcinomas.",
author = "Son, {Hyun Bae} and Han, {Chul Ju} and Kim, {Beung Il} and Jin Kim and Jeong, {Sook Hyang} and Kim, {You Cheoul} and Lee, {Jhin Oh} and Choi, {Chang Yun} and Im, {Sang Mu}",
year = "2002",
month = "1",
day = "1",
language = "English",
volume = "8",
pages = "472--480",
journal = "Taehan Kan Hakhoe chi = The Korean journal of hepatology",
issn = "1226-0479",
publisher = "Korean Association for the Study of the Liver",
number = "4",

}

Son, HB, Han, CJ, Kim, BI, Kim, J, Jeong, SH, Kim, YC, Lee, JO, Choi, CY & Im, SM 2002, 'Evaluation of various hepatic lesions with positron emission tomography', Taehan Kan Hakhoe chi = The Korean journal of hepatology, vol. 8, no. 4, pp. 472-480.

Evaluation of various hepatic lesions with positron emission tomography. / Son, Hyun Bae; Han, Chul Ju; Kim, Beung Il; Kim, Jin; Jeong, Sook Hyang; Kim, You Cheoul; Lee, Jhin Oh; Choi, Chang Yun; Im, Sang Mu.

In: Taehan Kan Hakhoe chi = The Korean journal of hepatology, Vol. 8, No. 4, 01.01.2002, p. 472-480.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Evaluation of various hepatic lesions with positron emission tomography

AU - Son, Hyun Bae

AU - Han, Chul Ju

AU - Kim, Beung Il

AU - Kim, Jin

AU - Jeong, Sook Hyang

AU - Kim, You Cheoul

AU - Lee, Jhin Oh

AU - Choi, Chang Yun

AU - Im, Sang Mu

PY - 2002/1/1

Y1 - 2002/1/1

N2 - BACKGROUND/AIMS: [18F]FDG-PET is a functional imaging modality reflecting cellular glucose metabolism. In most malignant cells, accumulation and trapping of [18F]FDG allows the visualization of increased uptake compared with normal cells. The aim of this study was to assess the value of PET in differentiating benign from malignant hepatic lesions and to determine in which types of hepatic tumors PET can help evaluate stage, monitor response to therapy, and detect recurrence. METHODS: Eighty patients with liver lesions were enrolled (hepatocellular carcinoma 34, cholangiocarcinoma 8, metastatic liver cancer 25, hemangioma 6, liver abscess 7). Liver metastases were 22 adenocarcinoma, 2 lymphoma, 2 squamous cell carcinoma. The PET images of these patients were analyzed. SUV and lesion-to-normal liver background SUV ratio were obtained and compared among the disease groups. RESULTS: All liver metastases and all cholangiocarcinomas had increased uptake value, with SUV ratios greater than 2. Hepatocellular carcinoma had SUV ratios greater than 2 in 20 of 34 patients (59%). All hemangiomas had poor uptake, a SUV ratio of less than 2. All liver abscesses showed definite uptake. CONCLUSIONS: The PET technique using FDG static imaging was useful in differentiating malignant from benign lesions of the liver in limited situations. Limitations included false negative results in some patients with hepatocellular carcinoma. Liver abscesses raised problems in differential diagnosis from malignant liver tumors. The findings of this study suggest that the PET technique might be applied in tumor staging and the detection of recurrence, as well as monitoring responses to therapy for all adenocarcinomas and some hepatocellular carcinomas.

AB - BACKGROUND/AIMS: [18F]FDG-PET is a functional imaging modality reflecting cellular glucose metabolism. In most malignant cells, accumulation and trapping of [18F]FDG allows the visualization of increased uptake compared with normal cells. The aim of this study was to assess the value of PET in differentiating benign from malignant hepatic lesions and to determine in which types of hepatic tumors PET can help evaluate stage, monitor response to therapy, and detect recurrence. METHODS: Eighty patients with liver lesions were enrolled (hepatocellular carcinoma 34, cholangiocarcinoma 8, metastatic liver cancer 25, hemangioma 6, liver abscess 7). Liver metastases were 22 adenocarcinoma, 2 lymphoma, 2 squamous cell carcinoma. The PET images of these patients were analyzed. SUV and lesion-to-normal liver background SUV ratio were obtained and compared among the disease groups. RESULTS: All liver metastases and all cholangiocarcinomas had increased uptake value, with SUV ratios greater than 2. Hepatocellular carcinoma had SUV ratios greater than 2 in 20 of 34 patients (59%). All hemangiomas had poor uptake, a SUV ratio of less than 2. All liver abscesses showed definite uptake. CONCLUSIONS: The PET technique using FDG static imaging was useful in differentiating malignant from benign lesions of the liver in limited situations. Limitations included false negative results in some patients with hepatocellular carcinoma. Liver abscesses raised problems in differential diagnosis from malignant liver tumors. The findings of this study suggest that the PET technique might be applied in tumor staging and the detection of recurrence, as well as monitoring responses to therapy for all adenocarcinomas and some hepatocellular carcinomas.

UR - http://www.scopus.com/inward/record.url?scp=2342571791&partnerID=8YFLogxK

M3 - Article

VL - 8

SP - 472

EP - 480

JO - Taehan Kan Hakhoe chi = The Korean journal of hepatology

JF - Taehan Kan Hakhoe chi = The Korean journal of hepatology

SN - 1226-0479

IS - 4

ER -